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学科主题: 临床医学
题名:
Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats
作者: Wu, Yu; Li, Lin; Wen, Tao; Li, Yue-Qi
关键词: carbon tetrachloride ; oxidative stress ; acute liver injury ; ROS ; echinacoside
刊名: TOXICOLOGY
发表日期: 2007-03-22
DOI: 10.1016/j.tox.2006.12.013
卷: 232, 期:1-2, 页:50-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: DRUG-INDUCED HEPATOTOXICITY ; ACUTE LIVER-INJURY ; LIPID-PEROXIDATION ; REACTIVE OXYGEN ; OXIDATIVE STRESS ; MECHANISMS ; DISEASE ; SUPEROXIDE ; APOPTOSIS ; SYSTEMS
英文摘要:

The aim of this study was to investigate the possible protective effects of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on the free radical damage of liver caused by carbon tetrachloride in rats. Treatment of rats with carbon tetrachloride produced severe liver injury, as demonstrated by dramatic elevation of serum ALT, AST levels and typical histopathological changes including hepatocyte necrosis or apoptosis, haemorrhage, fatty degeneration, etc. In addition, carbon tetrachloride administration caused oxidative stress in rats, as evidenced by increased reactive oxygen species (ROS) production and MDA concentrations in the liver of rats, along with a remarkable reduction in hepatic SOD activity and GSH content. However, simultaneous treatment with echinacoside (50 mg/kg, intraperitoneally) significantly attenuated carbon tetrachloride-induced hepatotoxicity. The results showed that serum ALT, AST levels and hepatic MDA content as well as ROS production were reduced dramatically, and hepatic SOD activity and GSH content were restored remarkably by echinacoside administration, as compared to the carbon tetrachloride-treated rats. Moreover, the histopathological damage of liver and the number of apoptotic hepatocytes were also significantly ameliorated by echinacoside treatment. It is therefore suggested that echinacoside can provide a definite protective effect against acute hepatic injury caused by CCl4 in rats, which may mainly be associated with its antioxidative effect. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000245345200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56196
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.302th Hosp PLA, Inst Liver Dis, Beijing 100039, Peoples R China
2.Peking Univ, Hosp 3, Res Ctr Digest Dis, Beijing 100083, Peoples R China

Recommended Citation:
Wu, Yu,Li, Lin,Wen, Tao,et al. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats[J]. TOXICOLOGY,2007,232(1-2):50-56.
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