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Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats
Wu, Yu; Li, Lin; Wen, Tao; Li, Yue-Qi
关键词Carbon Tetrachloride Oxidative Stress Acute Liver Injury Ros Echinacoside
刊名TOXICOLOGY
2007-03-22
DOI10.1016/j.tox.2006.12.013
232期:1-2页:50-56
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]DRUG-INDUCED HEPATOTOXICITY ; ACUTE LIVER-INJURY ; LIPID-PEROXIDATION ; REACTIVE OXYGEN ; OXIDATIVE STRESS ; MECHANISMS ; DISEASE ; SUPEROXIDE ; APOPTOSIS ; SYSTEMS
英文摘要

The aim of this study was to investigate the possible protective effects of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on the free radical damage of liver caused by carbon tetrachloride in rats. Treatment of rats with carbon tetrachloride produced severe liver injury, as demonstrated by dramatic elevation of serum ALT, AST levels and typical histopathological changes including hepatocyte necrosis or apoptosis, haemorrhage, fatty degeneration, etc. In addition, carbon tetrachloride administration caused oxidative stress in rats, as evidenced by increased reactive oxygen species (ROS) production and MDA concentrations in the liver of rats, along with a remarkable reduction in hepatic SOD activity and GSH content. However, simultaneous treatment with echinacoside (50 mg/kg, intraperitoneally) significantly attenuated carbon tetrachloride-induced hepatotoxicity. The results showed that serum ALT, AST levels and hepatic MDA content as well as ROS production were reduced dramatically, and hepatic SOD activity and GSH content were restored remarkably by echinacoside administration, as compared to the carbon tetrachloride-treated rats. Moreover, the histopathological damage of liver and the number of apoptotic hepatocytes were also significantly ameliorated by echinacoside treatment. It is therefore suggested that echinacoside can provide a definite protective effect against acute hepatic injury caused by CCl4 in rats, which may mainly be associated with its antioxidative effect. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000245345200005
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56196
专题北京大学第三临床医学院
作者单位1.302th Hosp PLA, Inst Liver Dis, Beijing 100039, Peoples R China
2.Peking Univ, Hosp 3, Res Ctr Digest Dis, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yu,Li, Lin,Wen, Tao,et al. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats[J]. TOXICOLOGY,2007,232(1-2):50-56.
APA Wu, Yu,Li, Lin,Wen, Tao,&Li, Yue-Qi.(2007).Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats.TOXICOLOGY,232(1-2),50-56.
MLA Wu, Yu,et al."Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats".TOXICOLOGY 232.1-2(2007):50-56.
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