学科主题 | 基础医学 |
Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update | |
Wang, Nanping1; Yin, Ruiying; Liu, Yan; Mao, Guangmei; Xi, Fang | |
关键词 | Atherosclerosis Gene Expression Peroxisome Proliferator-activated Receptor Myocardial Infarction Thiazolidinediones |
刊名 | CIRCULATION JOURNAL
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2011-03-01 | |
DOI | 10.1253/circj.CJ-11-0060 |
卷 | 75期:3页:528-535 |
收录类别 | SCI |
文章类型 | Review |
WOS标题词 | Science & Technology |
类目[WOS] | Cardiac & Cardiovascular Systems |
资助者 | National Natural Science Foundation ; Major National Basic Research Program ; National Natural Science Foundation ; Major National Basic Research Program |
研究领域[WOS] | Cardiovascular System & Cardiology |
关键词[WOS] | SMOOTH-MUSCLE-CELLS ; TYPE-2 DIABETES-MELLITUS ; LOW-DENSITY-LIPOPROTEIN ; VASCULAR ENDOTHELIAL-CELLS ; E-DEFICIENT MICE ; PERCUTANEOUS CORONARY INTERVENTION ; TARGET VESSEL REVASCULARIZATION ; PIOGLITAZONE CLINICAL-TRIAL ; RANDOMIZED CONTROLLED-TRIAL ; INTIMA-MEDIA THICKNESS |
英文摘要 | Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a member of the ligand-activated nuclear receptor family. Thiazolidinediones, such as rosiglitazone and pioglitazone, are synthetic agonists selective for PPAR gamma and have been used in the clinical treatment of type 2 diabetes. However, beyond the metabolic effects on glycemic control, PPAR gamma and its ligands also have profound effects on cardiovascular biological and pathophysiological processes. As cardiovascular diseases are closely associated with insulin resistance, and the major cause of death and complications of type 2 diabetes, a comprehensive understanding of the cardiovascular roles of this receptor is critical for the rational application of the existing agonists and the future development of therapeutic modulators. Therefore, this review will focus on the recent advances regarding the cardiovascular functions of PPAR gamma and its recognized effects on major cardiovascular diseases, in particular, atherosclerosis and associated processes. (Circ J 2011; 75: 528-535) |
语种 | 英语 |
所属项目编号 | 30890041 ; 30931160434 ; 2010CB912502 |
资助者 | National Natural Science Foundation ; Major National Basic Research Program ; National Natural Science Foundation ; Major National Basic Research Program |
WOS记录号 | WOS:000287991500003 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/56200 |
Collection | 北京大学基础医学院_心血管所 |
作者单位 | 1.Peking Univ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China 2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China |
Recommended Citation GB/T 7714 | Wang, Nanping,Yin, Ruiying,Liu, Yan,et al. Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update[J]. CIRCULATION JOURNAL,2011,75(3):528-535. |
APA | Wang, Nanping,Yin, Ruiying,Liu, Yan,Mao, Guangmei,&Xi, Fang.(2011).Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update.CIRCULATION JOURNAL,75(3),528-535. |
MLA | Wang, Nanping,et al."Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update".CIRCULATION JOURNAL 75.3(2011):528-535. |
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