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Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update
Wang, Nanping1; Yin, Ruiying; Liu, Yan; Mao, Guangmei; Xi, Fang
关键词Atherosclerosis Gene Expression Peroxisome Proliferator-activated Receptor Myocardial Infarction Thiazolidinediones
刊名CIRCULATION JOURNAL
2011-03-01
DOI10.1253/circj.CJ-11-0060
75期:3页:528-535
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Natural Science Foundation ; Major National Basic Research Program ; National Natural Science Foundation ; Major National Basic Research Program
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; TYPE-2 DIABETES-MELLITUS ; LOW-DENSITY-LIPOPROTEIN ; VASCULAR ENDOTHELIAL-CELLS ; E-DEFICIENT MICE ; PERCUTANEOUS CORONARY INTERVENTION ; TARGET VESSEL REVASCULARIZATION ; PIOGLITAZONE CLINICAL-TRIAL ; RANDOMIZED CONTROLLED-TRIAL ; INTIMA-MEDIA THICKNESS
英文摘要

Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a member of the ligand-activated nuclear receptor family. Thiazolidinediones, such as rosiglitazone and pioglitazone, are synthetic agonists selective for PPAR gamma and have been used in the clinical treatment of type 2 diabetes. However, beyond the metabolic effects on glycemic control, PPAR gamma and its ligands also have profound effects on cardiovascular biological and pathophysiological processes. As cardiovascular diseases are closely associated with insulin resistance, and the major cause of death and complications of type 2 diabetes, a comprehensive understanding of the cardiovascular roles of this receptor is critical for the rational application of the existing agonists and the future development of therapeutic modulators. Therefore, this review will focus on the recent advances regarding the cardiovascular functions of PPAR gamma and its recognized effects on major cardiovascular diseases, in particular, atherosclerosis and associated processes. (Circ J 2011; 75: 528-535)

语种英语
所属项目编号30890041 ; 30931160434 ; 2010CB912502
资助者National Natural Science Foundation ; Major National Basic Research Program ; National Natural Science Foundation ; Major National Basic Research Program
WOS记录号WOS:000287991500003
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被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56200
专题基础医学院_心血管所
作者单位1.Peking Univ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
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Wang, Nanping,Yin, Ruiying,Liu, Yan,et al. Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update[J]. CIRCULATION JOURNAL,2011,75(3):528-535.
APA Wang, Nanping,Yin, Ruiying,Liu, Yan,Mao, Guangmei,&Xi, Fang.(2011).Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update.CIRCULATION JOURNAL,75(3),528-535.
MLA Wang, Nanping,et al."Role of Peroxisome Proliferator-Activated Receptor-gamma in Atherosclerosis - An Update".CIRCULATION JOURNAL 75.3(2011):528-535.
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