IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation
Chang, Ying-Jun1,2; Zhao, Xiang-Yu1,2; Huo, Ming-Rui1,2; Xu, Lan-Ping1,2; Liu, Dai-Hong1,2; Liu, Kai-Yan1,2; Huang, Xiao-Jun1,2
关键词Immune Reconstitution Haploidentical Hla-identical Hematopoietic Stem Cell Transplantation
刊名JOURNAL OF CLINICAL IMMUNOLOGY
2012-04-01
DOI10.1007/s10875-011-9630-7
32期:2页:268-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]STEM-CELL TRANSPLANTATION ; VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; EARLY LYMPHOCYTE RECOVERY ; RISK ACUTE-LEUKEMIA ; HEMATOLOGIC MALIGNANCIES ; PREDICTS SUPERIOR ; T-LYMPHOCYTES ; CHRONIC GRAFT ; HAPLOTYPE
英文摘要

In this study, we prospectively investigated the immune reconstitution in patients with hematological malignancies after human leukocyte antigen (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and HLA-matched transplant (25 cases). Transplant-related mortality, relapse, leukemia-free survival, and overall survival were similar between the two transplant strategies, although the cumulative incidence of CMV antigenemia was significantly higher in haploidentical recipients than in HLA-matched recipients (49.9 +/- 7.2% versus 13 +/- 7%, P=0.007). Compared with HLA-matched recipients, T-cell subset and dendritic cell subgroup cell counts in the first 90 days after grafting were lower in haploidentical recipients. The difference was most striking for CD4(+) and CD4(+) naive T cells. Reconstitution of B cells and monocytes was comparable between groups. T cells appeared equally functional in both groups among patients without graft-versus-host disease. Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation.

语种英语
WOS记录号WOS:000302615200008
项目编号30725038 ; 30971292 ; 30800485 ; 2008B05
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel program
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56202
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2012,32(2):268-280.
APA Chang, Ying-Jun.,Zhao, Xiang-Yu.,Huo, Ming-Rui.,Xu, Lan-Ping.,Liu, Dai-Hong.,...&Huang, Xiao-Jun.(2012).Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation.JOURNAL OF CLINICAL IMMUNOLOGY,32(2),268-280.
MLA Chang, Ying-Jun,et al."Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation".JOURNAL OF CLINICAL IMMUNOLOGY 32.2(2012):268-280.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
百度学术
百度学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
必应学术
必应学术中相似的文章
[Chang, Ying-Jun]的文章
[Zhao, Xiang-Yu]的文章
[Huo, Ming-Rui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。