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学科主题: 临床医学
题名:
Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation
作者: Chang, Ying-Jun1,2; Zhao, Xiang-Yu1,2; Huo, Ming-Rui1,2; Xu, Lan-Ping1,2; Liu, Dai-Hong1,2; Liu, Kai-Yan1,2; Huang, Xiao-Jun1,2
关键词: Immune reconstitution ; haploidentical ; HLA-identical ; hematopoietic stem cell transplantation
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2012-04-01
DOI: 10.1007/s10875-011-9630-7
卷: 32, 期:2, 页:268-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; EARLY LYMPHOCYTE RECOVERY ; RISK ACUTE-LEUKEMIA ; HEMATOLOGIC MALIGNANCIES ; PREDICTS SUPERIOR ; T-LYMPHOCYTES ; CHRONIC GRAFT ; HAPLOTYPE
英文摘要:

In this study, we prospectively investigated the immune reconstitution in patients with hematological malignancies after human leukocyte antigen (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and HLA-matched transplant (25 cases). Transplant-related mortality, relapse, leukemia-free survival, and overall survival were similar between the two transplant strategies, although the cumulative incidence of CMV antigenemia was significantly higher in haploidentical recipients than in HLA-matched recipients (49.9 +/- 7.2% versus 13 +/- 7%, P=0.007). Compared with HLA-matched recipients, T-cell subset and dendritic cell subgroup cell counts in the first 90 days after grafting were lower in haploidentical recipients. The difference was most striking for CD4(+) and CD4(+) naive T cells. Reconstitution of B cells and monocytes was comparable between groups. T cells appeared equally functional in both groups among patients without graft-versus-host disease. Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation.

语种: 英语
所属项目编号: 30725038 ; 30971292 ; 30800485 ; 2008B05
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel program
WOS记录号: WOS:000302615200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56202
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2012,32(2):268-280.
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