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学科主题: 临床医学
题名:
Frequency of T-cell FoxP3(+) Treg and CD4(+)/CD8(+) PD-1 expression is related to HBeAg seroconversion in hepatitis B patients on pegylated interferon
作者: Ma Hui1; Zhang Heng-hui2; Wei Lai2
关键词: chronic hepatitis B ; dendritic cells ; pegylated interferon alpha-2b ; programmed death 1 ; regulatory T cell
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-01-20
DOI: 10.3760/cma.j.issn.0366-6999.20120535
卷: 126, 期:2, 页:267-273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: DENDRITIC CELLS ; REGULATORY CELLS ; CONTROLLED TRIAL ; THERAPY ; ALPHA ; BLOOD ; MECHANISMS ; LAMIVUDINE
英文摘要:

Background Host immune responses against hepatitis B virus (HBV) induced by antiviral therapy play a crucial role in viral clearance. To further investigate the immune mechanisms underlying the differences between respondents and non-respondents, we analyzed myeloid dendritic cells (mDCs), plasmacytoid dendritic cells (pDCs), FoxP3(+) regulatory T cells (FoxP3(+) Treg) and programmed death 1 (PD-1) expression in CD4(+)/CD8(+) T cells in chronic hepatitis B patients undergoing pegylated interferon (PegIFN)alpha-2b treatment.

Methods Patients received PegIFN alpha-2b for 24 or 48 weeks, with follow-up at 24 weeks. The frequencies of mDCs, pDCs, FoxP3(+) Treg, and PD-1 expression by CD4(+)/CD8(+) T cells were evaluated by flow cytometry at baseline, weeks 4 and 12, end of treatment, and follow-up (12/24 weeks).

Results In HBeAg seroconverters (respondents), the mDC relative frequency decreased at week 4 and then rebounded at week 12. The pDC relative frequency decreased consistently. In non-HBeAg seroconverters (non-respondents), both mDC and pDC frequencies decreased slightly. The FoxP3(+) Treg relative frequency decreased during treatment and remained low during follow-up in respondents, while in non-respondents it decreased slightly during therapy but rebounded after discontinuation. In patients with HBeAg <17.55 PEI-U/ml at week 12 and <8.52 PEI-U/ml at week 24, the FoxP3(+) Treg frequency decreased during treatment and at follow-up. In respondents, CD4(+)PD-1 and CD8(+)PD-1 levels decreased at week 4 and remained low at week 12. In non-respondents, PD-1 expression decreased at week 4 but rebounded at week 12.

Conclusions The results indicate that the dynamic changes in DCs, FoxP3(+) Treg frequency, and PD-1 expression by CD4(+) and CD8(+) T cells exhibit different trends in HBeAg and non-HBeAg seroconversion patients. During PegIFN alpha-2b treatment of chronic hepatitis B patients, these changes may be of predictive value for HBeAg seroconversion. HBsAg and HBeAg levels are related to FoxP3(+) Treg frequency.

语种: 英语
所属项目编号: 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30571639 ; 2008ZX10002-004 ; 2008ZX10002-012 ; 2008ZX10002-013 ; RDC 2009-13
项目资助者: Chinese Basic Research Foundation "973" ; "863" Program ; NSFC ; National Science and Technology Major Project for Infectious Diseases Control ; Peking University People&prime ; s Hospital Research Development Funds ; Key Clinical Research Program of the Ministry of Health
WOS记录号: WOS:000319632800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56203
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Hepatol, Dept Hepatol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ma Hui,Zhang Heng-hui,Wei Lai. Frequency of T-cell FoxP3(+) Treg and CD4(+)/CD8(+) PD-1 expression is related to HBeAg seroconversion in hepatitis B patients on pegylated interferon[J]. CHINESE MEDICAL JOURNAL,2013,126(2):267-273.
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