IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Studies on carbohydrates LIV. Studies on the synthesis of an analogue of SM(3), a cancer associated carbohydrate antigen of HCC
Li, Q; Li, Q; Li, H; Su, B; Lou, QH; Cai, MS; Li, ZJ
关键词Synthesis Human Heptacellular Carcinoma Carbohydrate Antigen Sulfated
刊名ACTA CHIMICA SINICA
2002-08-01
60期:8页:1473-1478
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]HUMAN HEPATOCELLULAR-CARCINOMA ; MONOCLONAL-ANTIBODIES ; TUMOR-CELLS ; GLYCOSIDES ; VACCINES
英文摘要

SM(3) is a sulfated glycolipid, in which the neutral sugar chain is modified by sulfate residue. The amount of sulfated glycolipids in normal liver cell is very small, however, highly expression of SM(3) is found in human heptacellular carcinoma (HCC) cells and tissues. Therefore, it is suggested that SM3 may be the important cancer associated carbohydrate antigen of HCC. In this paper, one spacer-armed analogue of a disaccharide SM(3) was synthesized for the first time via multi-step synthetic method. The target compound is suitable for conjugation to a carrier by the presence of a 2-amino ethyl spacer, and therefore is useful for application in immunological study later.

语种中文
WOS记录号WOS:000177641800020
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56204
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Natl Res Labs Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, Q,Li, Q,Li, H,et al. Studies on carbohydrates LIV. Studies on the synthesis of an analogue of SM(3), a cancer associated carbohydrate antigen of HCC[J]. ACTA CHIMICA SINICA,2002,60(8):1473-1478.
APA Li, Q.,Li, Q.,Li, H.,Su, B.,Lou, QH.,...&Li, ZJ.(2002).Studies on carbohydrates LIV. Studies on the synthesis of an analogue of SM(3), a cancer associated carbohydrate antigen of HCC.ACTA CHIMICA SINICA,60(8),1473-1478.
MLA Li, Q,et al."Studies on carbohydrates LIV. Studies on the synthesis of an analogue of SM(3), a cancer associated carbohydrate antigen of HCC".ACTA CHIMICA SINICA 60.8(2002):1473-1478.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Q]的文章
[Li, Q]的文章
[Li, H]的文章
百度学术
百度学术中相似的文章
[Li, Q]的文章
[Li, Q]的文章
[Li, H]的文章
必应学术
必应学术中相似的文章
[Li, Q]的文章
[Li, Q]的文章
[Li, H]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。