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学科主题: 临床医学
题名:
Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies
作者: Guan, Ming2; Liu, Li3; Zhao, Xiaosu4; Wu, Qi5; Yu, Bo5; Shao, Yong5; Yang, Hong6; Fu, Xinrong7; Wan, Jun5,7; Zhang, Wei1
关键词: Acute lymphoblastic leukemia (ALL) ; Acute myelogenous leukemia (AML)
刊名: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
发表日期: 2011-02-01
DOI: 10.3816/CLML.2011.n.006
卷: 11, 期:1, 页:50-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; CELL-LINES ; EPHRIN LIGANDS ; RECEPTORS ; CANCER ; DELETION
英文摘要:

Background: EphA3 is a component of the Eph receptor family, the largest subgroup of the receptor tyrosine kinase (RTK) family. A recent array-based study implicated the presence of copy-number variations (CNVs) of EphA3 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees, and have been found to associate with various types of diseases including hematologic malignancies. However, most of the current studies focused on the genome-wide screening of CNVs, and the functional impact of such regions needs to be extensively investigated in large number of clinical samples. Patients and Methods: In our study, we collected 617 bone marrow samples from multiple types of hematologic malignancies as well as healthy controls. DNA copy numbers and mRNA levels of EphA3 in these samples were examined. Results: We found significant association between the CNVs of EphA3 and these hematologic malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also observed a positive correlation between the relative mRNA level and gene dosage of EphA3. Conclusion: The CNVs of EphA3 were associated with multiple types of hematologic malignancies including ALL, AML, CLL, CML, MM, and MDS.

语种: 英语
项目资助者: Shenzhen-Hong Kong Technological Cooperation
WOS记录号: WOS:000289383600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56206
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Capital Med Univ, Dept Anat, Beijing, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Jinan 510632, Guangdong, Peoples R China
4.Peking Univ, Inst Hematol, Dept Hematol, Peking Univ Peoples Hosp, Beijing 100871, Peoples R China
5.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol, Dept Life Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Guan, Ming,Liu, Li,Zhao, Xiaosu,et al. Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies[J]. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA,2011,11(1):50-53.
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