IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies
Guan, Ming2; Liu, Li3; Zhao, Xiaosu4; Wu, Qi5; Yu, Bo5; Shao, Yong5; Yang, Hong6; Fu, Xinrong7; Wan, Jun5,7; Zhang, Wei1
关键词Acute Lymphoblastic Leukemia (All) Acute Myelogenous Leukemia (Aml)
刊名CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
2011-02-01
DOI10.3816/CLML.2011.n.006
11期:1页:50-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; CELL-LINES ; EPHRIN LIGANDS ; RECEPTORS ; CANCER ; DELETION
英文摘要

Background: EphA3 is a component of the Eph receptor family, the largest subgroup of the receptor tyrosine kinase (RTK) family. A recent array-based study implicated the presence of copy-number variations (CNVs) of EphA3 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees, and have been found to associate with various types of diseases including hematologic malignancies. However, most of the current studies focused on the genome-wide screening of CNVs, and the functional impact of such regions needs to be extensively investigated in large number of clinical samples. Patients and Methods: In our study, we collected 617 bone marrow samples from multiple types of hematologic malignancies as well as healthy controls. DNA copy numbers and mRNA levels of EphA3 in these samples were examined. Results: We found significant association between the CNVs of EphA3 and these hematologic malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also observed a positive correlation between the relative mRNA level and gene dosage of EphA3. Conclusion: The CNVs of EphA3 were associated with multiple types of hematologic malignancies including ALL, AML, CLL, CML, MM, and MDS.

语种英语
WOS记录号WOS:000289383600007
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56206
专题北京大学第二临床医学院_血液科
北京大学临床肿瘤学院_护理部
作者单位1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Capital Med Univ, Dept Anat, Beijing, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Jinan 510632, Guangdong, Peoples R China
4.Peking Univ, Inst Hematol, Dept Hematol, Peking Univ Peoples Hosp, Beijing 100871, Peoples R China
5.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol, Dept Life Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Guan, Ming,Liu, Li,Zhao, Xiaosu,et al. Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies[J]. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA,2011,11(1):50-53.
APA Guan, Ming.,Liu, Li.,Zhao, Xiaosu.,Wu, Qi.,Yu, Bo.,...&Zhang, Wei.(2011).Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies.CLINICAL LYMPHOMA MYELOMA & LEUKEMIA,11(1),50-53.
MLA Guan, Ming,et al."Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies".CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 11.1(2011):50-53.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guan, Ming]的文章
[Liu, Li]的文章
[Zhao, Xiaosu]的文章
百度学术
百度学术中相似的文章
[Guan, Ming]的文章
[Liu, Li]的文章
[Zhao, Xiaosu]的文章
必应学术
必应学术中相似的文章
[Guan, Ming]的文章
[Liu, Li]的文章
[Zhao, Xiaosu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。