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学科主题: 临床医学
题名:
Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome
作者: Chen, Xinwang1; Jia, Xiao1; Qiao, Jie2; Guan, Youfei1; Kang, Jihong1
关键词: polycystic ovary syndrome ; adipokines ; obesity ; adipose tissue
刊名: JOURNAL OF MOLECULAR ENDOCRINOLOGY
发表日期: 2013-04-01
DOI: 10.1530/JME-12-0247
卷: 50, 期:2, 页:R21-R37
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: BODY-MASS INDEX ; ACTIVATED PROTEIN-KINASE ; COLONY-ENHANCING FACTOR ; SERUM LEPTIN LEVELS ; GELATINASE-ASSOCIATED LIPOCALIN ; PLASMA VISFATIN CONCENTRATIONS ; DIABETES-SUSCEPTIBILITY GENES ; SUBCUTANEOUS ADIPOSE-TISSUE ; VASCULAR ENDOTHELIAL-CELLS ; MESSENGER-RIBONUCLEIC-ACID
英文摘要:

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

语种: 英语
所属项目编号: 81100398 ; 81270943 ; 20100001120036
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000317954000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56214
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Xinwang,Jia, Xiao,Qiao, Jie,et al. Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome[J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY,2013,50(2):R21-R37.
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