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Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome
Chen, Xinwang1; Jia, Xiao1; Qiao, Jie2; Guan, Youfei1; Kang, Jihong1
关键词Polycystic Ovary Syndrome Adipokines Obesity Adipose Tissue
刊名JOURNAL OF MOLECULAR ENDOCRINOLOGY
2013-04-01
DOI10.1530/JME-12-0247
50期:2页:R21-R37
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]BODY-MASS INDEX ; ACTIVATED PROTEIN-KINASE ; COLONY-ENHANCING FACTOR ; SERUM LEPTIN LEVELS ; GELATINASE-ASSOCIATED LIPOCALIN ; PLASMA VISFATIN CONCENTRATIONS ; DIABETES-SUSCEPTIBILITY GENES ; SUBCUTANEOUS ADIPOSE-TISSUE ; VASCULAR ENDOTHELIAL-CELLS ; MESSENGER-RIBONUCLEIC-ACID
英文摘要

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

语种英语
WOS记录号WOS:000317954000001
项目编号81100398 ; 81270943 ; 20100001120036
资助机构National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56214
专题北京大学基础医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xinwang,Jia, Xiao,Qiao, Jie,et al. Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome[J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY,2013,50(2):R21-R37.
APA Chen, Xinwang,Jia, Xiao,Qiao, Jie,Guan, Youfei,&Kang, Jihong.(2013).Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome.JOURNAL OF MOLECULAR ENDOCRINOLOGY,50(2),R21-R37.
MLA Chen, Xinwang,et al."Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome".JOURNAL OF MOLECULAR ENDOCRINOLOGY 50.2(2013):R21-R37.
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