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学科主题临床医学
Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis
Fang, Zhengyu; Wu, Lamei; Wang, Luo; Yang, Yang; Meng, Yusheng; Yang, Hongyu
刊名ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
2014
DOI10.1016/j.oooo.2013.09.007
117期:1页:89-95
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者Natural Science Foundation of Guangdong Province ; Fundamental Research Plan of Shenzhen City ; Natural Science Foundation of Guangdong Province ; Fundamental Research Plan of Shenzhen City
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]ORAL-CAVITY ; BLADDER-CARCINOMA ; RELEVANCE
英文摘要

Objective. The aim of this study was to examine the expression of several cancer-related long non-coding RNAs (lncRNAs) in patients with tongue squamous cell carcinoma (TSCC) and to explore its clinical significance.

Study Design. A total of 94 TSCC tissue specimens and matched adjacent normal tissue specimens were collected from patients undergoing surgery for TSCC. Differences in the expression of cancer-related lncRNAs were examined via quantitative reverse transcriptase polymerase chain reaction. WST-1 assay and transwell migration assay were carried out to estimate the proliferation and migration abilities of TSCC cells with different expression levels of urothelial cancer-associated 1 (UCA1) lncRNA.

Results. The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells.

Conclusions. Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis.

语种英语
所属项目编号S2012010010382 ; 201105140031398026 ; 20120601120612815
资助者Natural Science Foundation of Guangdong Province ; Fundamental Research Plan of Shenzhen City ; Natural Science Foundation of Guangdong Province ; Fundamental Research Plan of Shenzhen City
WOS记录号WOS:000328633800026
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56221
专题北京大学深圳医院
作者单位Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong Provi, Peoples R China
推荐引用方式
GB/T 7714
Fang, Zhengyu,Wu, Lamei,Wang, Luo,et al. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY,2014,117(1):89-95.
APA Fang, Zhengyu,Wu, Lamei,Wang, Luo,Yang, Yang,Meng, Yusheng,&Yang, Hongyu.(2014).Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis.ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY,117(1),89-95.
MLA Fang, Zhengyu,et al."Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis".ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 117.1(2014):89-95.
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