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学科主题: 临床医学
题名:
The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T-cell activation
作者: Cheng, YJ; Zhou, Q; Li, ZG
刊名: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
发表日期: 2005-03-01
DOI: 10.1111/j.1365-3083.2005.01553.x
卷: 61, 期:3, 页:260-265
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: HLA-DR MOLECULES ; MHC CLASS-II ; RHEUMATOID-ARTHRITIS ; AUTOIMMUNE ARTHRITIS ; CRYSTAL-STRUCTURE ; TRANSGENIC MICE ; SHARED EPITOPE ; SUSCEPTIBILITY ; BINDING ; HLA-DR4
英文摘要:

It has been known that rheumatoid arthritis (RA)-associated antigenic peptides CII263-272 are coupled with human leucocyte antigen (HLA)-DRB1 and recognized by T-cell receptor (TCR), which in turn induced T-cell proliferation and pathogenesis of RA. Non-T-cell-stimulating type II collagen (CII) peptides might be generated by removing the amino acids responsible for TCR contact and keeping the HLA-DR-binding residues intact. In this study, a panel of altered CII peptides (APs) with consecutive or single substitutions of the TCR-contacting residues were synthesized. Through peptide binding and T-cell activation assays, we demonstrated that altered CII263-272 peptides with substitution of the TCR-contacting residues did not or barely induced T-cell activation; one of the best non-T-cell-stimulating peptide AP268-270 inhibited the binding of wild-type CII263-272 to HLA-DR1 and T-cell activation triggered by wild-type CII263-272 and HA306-318 in a dose-response manner. These data suggest that removal of the TCR-contacting residues of C11263-272 leads to HLA-DRB1 binding and low T-cell-stimulating peptides, which could potentially inhibit the T-cell response induced by HLA-DRB1-binding antigenic peptides.

语种: 英语
WOS记录号: WOS:000228103000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56223
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Sch Med, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Cheng, YJ,Zhou, Q,Li, ZG. The inhibitory effect of altered collagen II peptide on HLA-DRB1-restricted T-cell activation[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2005,61(3):260-265.
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