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学科主题临床医学
Magnetic resonance imaging changes of thigh muscles in myopathy with antibodies to signal recognition particle
Zheng, Yiming1; Liu, Linlin1; Wang, Lu1; Xiao, Jiangxi2; Wang, Zhaoxia1; Lv, He1; Zhang, Wei1; Yuan, Yun1
关键词Myositis Mri Muscles
刊名RHEUMATOLOGY
2015-06-01
DOI10.1093/rheumatology/keu422
54期:6页:1017-1024
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
研究领域[WOS]Rheumatology
关键词[WOS]INCLUSION-BODY MYOSITIS ; JUVENILE DERMATOMYOSITIS ; INFLAMMATORY MYOPATHIES ; MUSCULAR-DYSTROPHY ; HISTOPATHOLOGICAL FEATURES ; MRI ; AUTOANTIBODIES ; POLYMYOSITIS ; THERAPY ; DISEASE
英文摘要

Objective. The aim of this study was to evaluate muscle MRI changes and the role of MRI in monitoring therapy in patients with myopathy associated with antibodies to signal recognition particle (anti-SRP myopathy).

Methods. We identified 12 patients with anti-SRP myopathy [6 females and 6 males; mean age of onset 38.5 years (s.d. 12.4), mean duration 22.8 months (s.d. 20.6). The main symptoms were proximal limb muscle weakness. Mean serum creatine kinase levels were moderately increased. Muscle biopsies revealed necrotizing myopathy in all patients, with obvious connective tissue proliferation in five patients and a single focus of lymphocytic infiltration in the endomysium in one. The myositis disease activity assessment (MYOACT) visual analogue scales scores were assessed. Muscle MRI was performed through the thighs. All patients were treated with corticosteroids and other immunosuppressive drugs.

Results. MRI revealed fatty infiltration and oedema in the thigh muscles of all 12 patients. Prominent fatty infiltration was present in 4 of the 12 patients. The hamstrings and adductor magnus were the most severely infiltrated and the quadriceps femoris the least. Obvious oedema was observed in 10 of the 12 patients, the most severely affected muscles being the vastus lateralis, rectus femoris, biceps femoris and adductor magnus, with relative sparing of the vastus intermedius. The degree of oedema was not correlated with creatine kinase levels or MYOACT scores. The four patients with striking fatty infiltration were refractory to therapy.

Conclusion. MRI of the thigh muscles shows a distinct pattern of oedema and fatty infiltration and can be used to monitor the treatment of patients with anti-SRP myopathy.

语种英语
所属项目编号2011ZX09307-001-07
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
WOS记录号WOS:000357429600008
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56225
专题北京大学第一临床医学院_神经内科
作者单位1.Peking Univ, Dept Neurol, Hosp 1, Beijing, Peoples R China
2.Peking Univ, Dept Radiol, Hosp 1, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Yiming,Liu, Linlin,Wang, Lu,et al. Magnetic resonance imaging changes of thigh muscles in myopathy with antibodies to signal recognition particle[J]. RHEUMATOLOGY,2015,54(6):1017-1024.
APA Zheng, Yiming.,Liu, Linlin.,Wang, Lu.,Xiao, Jiangxi.,Wang, Zhaoxia.,...&Yuan, Yun.(2015).Magnetic resonance imaging changes of thigh muscles in myopathy with antibodies to signal recognition particle.RHEUMATOLOGY,54(6),1017-1024.
MLA Zheng, Yiming,et al."Magnetic resonance imaging changes of thigh muscles in myopathy with antibodies to signal recognition particle".RHEUMATOLOGY 54.6(2015):1017-1024.
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