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(99)mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: A Multicenter Study
Zhu, Zhaohui1,2; Miao, Weibing3; Li, Qianwei4; Dai, Haojie5; Ma, Qingjie6; Wang, Feng7; Yang, Aiming8; Jia, Bing9; Jing, Xiaona1,2; Liu, Sha1,2; Shi, Jiyun9; Liu, Zhaofei9; Zhao, Zhoushe10; Wang, Fan9; Li, Fang1,2
关键词Tc-99m-3prgd2 Integrin Alpha(v)Beta(3) Lung Cancer Multicenter Study Spect
刊名JOURNAL OF NUCLEAR MEDICINE
2012-05-01
DOI10.2967/jnumed.111.098988
53期:5页:716-722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; CYCLIC RGD PEPTIDES ; ALPHA(V)BETA(3) INTEGRIN ; BREAST-CANCER ; TUMOR UPTAKE ; ANGIOGENESIS ; EXPRESSION ; F-18-GALACTO-RGD ; PHARMACOKINETICS ; BIODISTRIBUTION
英文摘要

Tc-99m-3PRGD2 is a new SPECT tracer targeting integrin alpha(V)beta(3) receptor for detecting tumors, imaging angiogenesis, and evaluating tumor response to therapy. A multicenter study was designed to investigate the efficacy of Tc-99m-3PRGD2 for the evaluation of patients with lung cancer. Methods: Seventy patients (51 men, 19 women; mean age +/- SD, 63 +/- 9 y) with a suspected lung lesion and for whom definite pathologic diagnosis was finally obtained (malignant, n = 58; benign, n = 12) were recruited from 6 centers. Whole-body planar scanning and chest SPECT were performed at 1 and 4 h, respectively, after intravenous injection of 11.1 MBq/kg (0.3 mCi/kg) of (99)mTc-3PRGD2. The images were read in consensus by 6 experienced nuclear medicine physicians masked to the source, history, and pathologic diagnosis. The tumor-to-background (T/B) ratios were calculated for semiquantitative analysis. A Student t test was used for statistical analysis, and a P value less than 0.05 was considered significant. Results: With low Tc-99m-3PRGD2 background in the lungs and mediastinum, most lung malignancies were prominent on the 1-h images (T/B ratio, 1.65 +/- 0.47 for the planar imaging and 2.78 +/- 1.52 for SPECT). The T/B ratios were significantly lower in the benign lesions (P < 0.05). The sensitivity was 88% for semiquantitative analysis and could reach 93%-97% in visual analysis when considering the volume effect, necrosis, and metastasis. However, the specificity was only 58%-67%. Most lymph node and bone metastases could also be detected. Conclusion: Tc-99m-3PRGD2 imaging at 1 h is sensitive for the detection of lung cancer, meriting further investigation of Tc-99m-3PRGD2 as a novel clinical tracer for integrin receptor imaging.

语种英语
WOS记录号WOS:000303782700013
项目编号Z111107058811096 ; 30870725 ; 30870728 ; 30930030 ; 30900373 ; 81000625 ; 81071189 ; 81171369 ; 81125011 ; 2011CB707703 ; 2011YQ030114 ; 2012ZX09102301-018
资助机构Capital Special Project for Featured Clinical Application ; National Natural Science Foundation of China (NSFC) ; Outstanding Youth Fund ; "973" project ; Ministry of Science and Technology of China
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56230
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Chinese Acad Med Sci, Dept Nucl Med, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Fujian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Fuzhou, Peoples R China
4.Third Mil Med Univ, Southwest Hosp, Dept Nucl Med, Chongqing, Peoples R China
5.Beijing Tongren Hosp, Dept Nucl Med, Beijing, Peoples R China
6.Jilin Univ, China Japan Union Hosp, Dept Nucl Med, Changchun 130023, Peoples R China
7.1st Hosp Nanjing, Dept Nucl Med, Nanjing, Jiangsu, Peoples R China
8.Xi An Jiao Tong Univ, Dept Nucl Med, Affiliated Hosp 1, Xian, Peoples R China
9.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
10.GE Healthcare, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Zhaohui,Miao, Weibing,Li, Qianwei,et al. (99)mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: A Multicenter Study[J]. JOURNAL OF NUCLEAR MEDICINE,2012,53(5):716-722.
APA Zhu, Zhaohui.,Miao, Weibing.,Li, Qianwei.,Dai, Haojie.,Ma, Qingjie.,...&Li, Fang.(2012).(99)mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: A Multicenter Study.JOURNAL OF NUCLEAR MEDICINE,53(5),716-722.
MLA Zhu, Zhaohui,et al."(99)mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: A Multicenter Study".JOURNAL OF NUCLEAR MEDICINE 53.5(2012):716-722.
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