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Significance of endogenous sulphur-containing gases in the cardiovascular system
Wang, Xin-Bao1; Jin, Hong-Fang1; Tang, Chao-Shu2,3; Du, Jun-Bao1,3
关键词Cardiovascular Gasotransmitters Hydrogen Sulphide Nitric Oxide Sulphur Dioxide
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2010-07-01
DOI10.1111/j.1440-1681.2009.05249.x
37期:7页:745-752
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]HYDROGEN-SULFIDE H2S ; SMOOTH-MUSCLE-CELLS ; ISCHEMIA-REPERFUSION INJURY ; PULMONARY BLOOD-FLOW ; K-ATP CHANNELS ; MYOCARDIAL INJURY ; OXIDIZED GLUTATHIONE ; DIOXIDE INHALATION ; HYPERTENSIVE-RATS ; OXIDATIVE STRESS
英文摘要

P>1. The sulphur-containing gases hydrogen sulphide and sulphur dioxide can be generated endogenously in mammalian tissues and exert significant biological effects in the cardiovascular system. Hydrogen sulphide is considered to be the third novel gasotransmitter in addition to nitric oxide and carbon monoxide. The present review describes the effects of hydrogen sulphide on the cardiovascular system and its possible mechanisms under physiological conditions. We also discuss the pathophysiological effects of hydrogen sulphide on cardiovascular diseases. The therapeutic potential of hydrogen sulphide is summarized.

2. We recently discovered that sulphur dioxide, another endogenous sulphur-containing gas, has important physiological and pathophysiological roles in the cardiovascular system. To some extent, the effect of sulphur dioxide is similar to that of the other gasotransmitters nitric oxide, carbon monoxide and hydrogen sulphide. Sulphur dioxide may also be a novel gas mediator in the cardiovascular system.

语种英语
WOS记录号WOS:000278917600017
项目编号30630031 ; 30425010 ; 30821001 ; 30801251 ; 20070001770 ; 307001 ; 20070001702 ; 2006CB503807
资助机构National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56234
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Minist Educ, Key Lab Mol Cardiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xin-Bao,Jin, Hong-Fang,Tang, Chao-Shu,et al. Significance of endogenous sulphur-containing gases in the cardiovascular system[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2010,37(7):745-752.
APA Wang, Xin-Bao,Jin, Hong-Fang,Tang, Chao-Shu,&Du, Jun-Bao.(2010).Significance of endogenous sulphur-containing gases in the cardiovascular system.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,37(7),745-752.
MLA Wang, Xin-Bao,et al."Significance of endogenous sulphur-containing gases in the cardiovascular system".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 37.7(2010):745-752.
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