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学科主题: 临床医学
题名:
Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway
作者: Han, Ying; Yi, Wenxia; Qin, Jiong; Zhao, Yang; Zhang, Jing; Chang, Xingzhi
关键词: Carbon monoxide ; Endoplasmic reticulum stress ; Neuronal damage ; Febrile seizure ; Hippocampus ; PERK
刊名: NEUROSCIENCE LETTERS
发表日期: 2015-01-12
DOI: 10.1016/j.neulet.2014.11.040
卷: 585, 页:126-131
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; NITRIC-OXIDE ; NEURONAL INJURY ; PROTECTS ; APOPTOSIS ; RAT ; PATHOGENESIS ; BRAIN ; ISCHEMIA ; KINASES
英文摘要:

Carbon monoxide (CO) is neuroprotective in various models of brain injury, but the precise mechanisms for this are yet to be established. In the present study, using a rat model of recurrent febrile seizures (FSs), we found an increase in plasma CO, evidence of neuronal damage and apoptosis, an increase in the expression of the endoplasmic reticulum stress (ERS) marker glucose-regulated protein 78 (GRP78) and C/EBP homologous binding protein (CHOP), and an increase in phosphorylated protein kinase RNA-like endoplasmic reticulum kinase (p-PERK)/eukaryotic translation initiation factor 2 alpha (p-eIF2 alpha) in the hippocampus after 10 FSs. Administration of Hemin (a CO donor) in FS rats alleviated the neuronal damage, reduced neuronal apoptosis, upregulated GRP78 expression, decreased CHOP, and increased p-PERK and p-eIF2 alpha expression in the hippocampus, compared to FS control rats. In contrast, treating FS rats with ZnPP-IX (a CO synthase inhibitor) aggravated the neuronal damage, enhanced neuronal apoptosis, downregulated GRP78 expression, increased CHOP, and decreased p-PERK and p-eIF2 alpha expression, compared to FS control rats. These results suggest that endogenous CO limits the neuronal damage induced by recurrent FSs, through the PERK-activated ERS pathway. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 81200998 ; 7092105 ; 7112131 ; 2012BAI03B02
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Key Clinical Project from the Ministry of Public Health ; National Key Technology R D Program
WOS记录号: WOS:000349194400025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56237
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing, Peoples R China

Recommended Citation:
Han, Ying,Yi, Wenxia,Qin, Jiong,et al. Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway[J]. NEUROSCIENCE LETTERS,2015,585:126-131.
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