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学科主题基础医学
Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides
Cao, LZ; Lin, ZB
关键词Ganoderma Lucidum Polysaccharides (Gl-ps) Dendritic Cells (Dc) Mixed Lymphocyte Culture (Mlc)
刊名IMMUNOLOGY LETTERS
2002-10-01
83期:3页:163-169
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ADAPTIVE IMMUNITY ; EXPRESSION ; GENERATION ; CYTOKINE ; INNATE
英文摘要

Ganoderma lucidum polysaccharides (Gl-PS) exhibits a variety of immunomodulatory activities, and dendritic cells (DC) are professional antigen presenting cells, which are pivotal for initiation of primary immune response. In this study, the regulatory effects of Gl-PS on maturation and function of cultured murine bone marrow derived DC were investigated in vitro. Gl-PS (0.8, 3.2, or 12.8 mug/ml) could increase the co-expression of CD11c and I-A/I-E molecules on DC surface, promote mRNA expression of cytokine IL-12 p40 in DC and augment protein production of IL-12 P40 in culture supernatants. The lymphocyte proliferation of mixed lymphocyte culture (MLC) induced by mature DC was enhanced by Gl-PS, either. Gl-PS was shown to promote not only the maturation of cultured murine bone marrow derived DC in vitro, but also the immune response initiation induced by DC. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000178372500004
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被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56238
专题北京大学基础医学院_药理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China
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Cao, LZ,Lin, ZB. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides[J]. IMMUNOLOGY LETTERS,2002,83(3):163-169.
APA Cao, LZ,&Lin, ZB.(2002).Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides.IMMUNOLOGY LETTERS,83(3),163-169.
MLA Cao, LZ,et al."Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides".IMMUNOLOGY LETTERS 83.3(2002):163-169.
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