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学科主题: 基础医学
题名:
Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides
作者: Cao, LZ; Lin, ZB
关键词: ganoderma lucidum polysaccharides (Gl-PS) ; dendritic cells (DC) ; mixed lymphocyte culture (MLC)
刊名: IMMUNOLOGY LETTERS
发表日期: 2002-10-01
卷: 83, 期:3, 页:163-169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ADAPTIVE IMMUNITY ; EXPRESSION ; GENERATION ; CYTOKINE ; INNATE
英文摘要:

Ganoderma lucidum polysaccharides (Gl-PS) exhibits a variety of immunomodulatory activities, and dendritic cells (DC) are professional antigen presenting cells, which are pivotal for initiation of primary immune response. In this study, the regulatory effects of Gl-PS on maturation and function of cultured murine bone marrow derived DC were investigated in vitro. Gl-PS (0.8, 3.2, or 12.8 mug/ml) could increase the co-expression of CD11c and I-A/I-E molecules on DC surface, promote mRNA expression of cytokine IL-12 p40 in DC and augment protein production of IL-12 P40 in culture supernatants. The lymphocyte proliferation of mixed lymphocyte culture (MLC) induced by mature DC was enhanced by Gl-PS, either. Gl-PS was shown to promote not only the maturation of cultured murine bone marrow derived DC in vitro, but also the immune response initiation induced by DC. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000178372500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56238
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Cao, LZ,Lin, ZB. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides[J]. IMMUNOLOGY LETTERS,2002,83(3):163-169.
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