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Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine
Chen, Zhuang1; Zhou, Shiqiang1; Jia, Yanxing1,2
刊名JOURNAL OF ORGANIC CHEMISTRY
2015-12-18
DOI10.1021/acs.joc.5b02402
80期:24页:12545-12551
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ASYMMETRIC TRANSFER HYDROGENATION ; CATALYZED DECARBOXYLATIVE ALLYLATION ; BETA-CARBOLINE DERIVATIVES ; ROOM-TEMPERATURE ; INDOLE ALKALOIDS ; COMPLEXES ; (+/-)-ASPIDOSPERMIDINE ; (+/-)-KOPSIHAINANINE ; BIOSYNTHESIS ; CARBAZOLONES
英文摘要

The formal synthesis of (+)-kopsihainanine A has been achieved via stereoselective reduction of tetracyclic iminium ion intermediates (24). However, attempts to synthesize (+)-limaspermidine by reduction of the same tetracyclic iminium ion intermediates have failed. The synthesis features a Suzuki cross-coupling reaction, a cyclization reaction mediated by trifluoromethanesulfonic anhydride, and stereoselective reduction of an iminium ion.

语种英语
WOS记录号WOS:000366877900062
项目编号21290183 ; 21572008 ; 21372017
资助机构National Natural Science Foundation of China ; State Key Laboratory of Bioorganic and Natural Products Chemistry
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56241
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
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GB/T 7714
Chen, Zhuang,Zhou, Shiqiang,Jia, Yanxing. Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(24):12545-12551.
APA Chen, Zhuang,Zhou, Shiqiang,&Jia, Yanxing.(2015).Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine.JOURNAL OF ORGANIC CHEMISTRY,80(24),12545-12551.
MLA Chen, Zhuang,et al."Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine".JOURNAL OF ORGANIC CHEMISTRY 80.24(2015):12545-12551.
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