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学科主题: 药学
题名:
Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine
作者: Chen, Zhuang1; Zhou, Shiqiang1; Jia, Yanxing1,2
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2015-12-18
DOI: 10.1021/acs.joc.5b02402
卷: 80, 期:24, 页:12545-12551
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ASYMMETRIC TRANSFER HYDROGENATION ; CATALYZED DECARBOXYLATIVE ALLYLATION ; BETA-CARBOLINE DERIVATIVES ; ROOM-TEMPERATURE ; INDOLE ALKALOIDS ; COMPLEXES ; (+/-)-ASPIDOSPERMIDINE ; (+/-)-KOPSIHAINANINE ; BIOSYNTHESIS ; CARBAZOLONES
英文摘要:

The formal synthesis of (+)-kopsihainanine A has been achieved via stereoselective reduction of tetracyclic iminium ion intermediates (24). However, attempts to synthesize (+)-limaspermidine by reduction of the same tetracyclic iminium ion intermediates have failed. The synthesis features a Suzuki cross-coupling reaction, a cyclization reaction mediated by trifluoromethanesulfonic anhydride, and stereoselective reduction of an iminium ion.

语种: 英语
所属项目编号: 21290183 ; 21572008 ; 21372017
项目资助者: National Natural Science Foundation of China ; State Key Laboratory of Bioorganic and Natural Products Chemistry
WOS记录号: WOS:000366877900062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56241
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Chen, Zhuang,Zhou, Shiqiang,Jia, Yanxing. Formal Synthesis of (+)-Kopsihainanine A and Synthetic Study toward (+)-Limaspermidine[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(24):12545-12551.
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