IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease
Chui De-Hua1; Tian Xiao-Sheng; Wang He-Cheng; Wang Wei; Xiao Wei-Zhong; Fan Dong-Sheng
关键词Brain Aging Preclinical Alzheimer&Prime s Disease (Pcad) Beta-amyloid (a Beta) P-tau
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2012-08-01
DOI10.3724/SP.J.1206.2012.00351
39期:8页:741-746
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]AMYLOID-BETA ; COGNITIVE IMPAIRMENT ; NEURODEGENERATION ; FORMALDEHYDE ; NEURONS ; ALPHA ; MICE ; AGGREGATION ; ACTIVATION ; BIOMARKERS
英文摘要

This article reviews the relationship between brain aging and Alzheimer′s disease (AD). Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself. A small percentage of individuals with normal antemortem psychometric scores meet the neuropathological criteria for AD termed "preclinical" AD (PCAD). PCAD and control subjects were compared for oxidative stress markers, amyloid beta-peptide, and identification of protein expression differences, and observed a significant increase in highly insoluble monomeric A beta 42, but no significant differences in oligomeric A beta nor in oxidative stress measurements between controls and PCAD subjects. Expression proteomics identified proteins whose trends in PCAD are indicative of cellular protection, possibly correlating with previous studies showing no cell loss in PCAD.

语种中文
WOS记录号WOS:000307851900010
项目编号30973145 ; 81171015 ; 81211140047 ; 20090001110058 ; 2012CB911000 ; 2012CB911004
资助机构National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education ; NHRD of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56242
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chui De-Hua,Tian Xiao-Sheng,Wang He-Cheng,et al. The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):741-746.
APA Chui De-Hua,Tian Xiao-Sheng,Wang He-Cheng,Wang Wei,Xiao Wei-Zhong,&Fan Dong-Sheng.(2012).The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(8),741-746.
MLA Chui De-Hua,et al."The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.8(2012):741-746.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chui De-Hua]的文章
[Tian Xiao-Sheng]的文章
[Wang He-Cheng]的文章
百度学术
百度学术中相似的文章
[Chui De-Hua]的文章
[Tian Xiao-Sheng]的文章
[Wang He-Cheng]的文章
必应学术
必应学术中相似的文章
[Chui De-Hua]的文章
[Tian Xiao-Sheng]的文章
[Wang He-Cheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。