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学科主题: 临床医学
题名:
The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease
作者: Chui De-Hua1; Tian Xiao-Sheng; Wang He-Cheng; Wang Wei; Xiao Wei-Zhong; Fan Dong-Sheng
关键词: brain aging ; preclinical Alzheimer&prime ; s disease (PCAD) ; beta-amyloid (A beta) ; p-Tau
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2012-08-01
DOI: 10.3724/SP.J.1206.2012.00351
卷: 39, 期:8, 页:741-746
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: AMYLOID-BETA ; COGNITIVE IMPAIRMENT ; NEURODEGENERATION ; FORMALDEHYDE ; NEURONS ; ALPHA ; MICE ; AGGREGATION ; ACTIVATION ; BIOMARKERS
英文摘要:

This article reviews the relationship between brain aging and Alzheimer′s disease (AD). Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself. A small percentage of individuals with normal antemortem psychometric scores meet the neuropathological criteria for AD termed "preclinical" AD (PCAD). PCAD and control subjects were compared for oxidative stress markers, amyloid beta-peptide, and identification of protein expression differences, and observed a significant increase in highly insoluble monomeric A beta 42, but no significant differences in oligomeric A beta nor in oxidative stress measurements between controls and PCAD subjects. Expression proteomics identified proteins whose trends in PCAD are indicative of cellular protection, possibly correlating with previous studies showing no cell loss in PCAD.

语种: 中文
所属项目编号: 30973145 ; 81171015 ; 81211140047 ; 20090001110058 ; 2012CB911000 ; 2012CB911004
项目资助者: National Natural Science Foundation of China ; Doctoral Fund of Ministry of Education ; NHRD of China
WOS记录号: WOS:000307851900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56242
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Chui De-Hua,Tian Xiao-Sheng,Wang He-Cheng,et al. The Relationship Between Brain Aging and Preclinical Alzheimer′s Disease[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):741-746.
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