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学科主题: 药学
题名:
Comparison of contents of five ephedrine alkaloids in three official origins of Ephedra Herb in China by high-performance liquid chromatography
作者: Hong, Hao1; Chen, Hu-Biao2; Yang, Dong-Hui1; Shang, Ming-Ying1; Wang, Xuan1; Cai, Shao-Qing1; Mikage, Masayuki3
关键词: Ephedra Herb ; Ephedra alkaloids ; Simultaneous determination ; Mahuang ; Species identification
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2011-07-01
DOI: 10.1007/s11418-011-0528-8
卷: 65, 期:3-4, 页:623-628
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

In the present paper, a fast and economical HPLC method [on a Phenomenex Polar-RP column with a solution of (phosphoric acid:triethylamine:dibutylamine:water = 0.40:0.1:0.2:499.3) and methanol] is developed, and applied for the determination of norephedrine, norpseudoephedrine, ephedrine (E), pseudoephedrine (PE) and methylephedrine (ME) in 64 samples of three species from main habitats in China. Quantitation data showed that total alkaloid content in Ephedra equisetina Bge. (2.708 +/- A 0.642%) is higher than that in E. sinica Stapf. (1.365 +/- A 0.624%) and E. intermedia Schrenk et C. A. Mey. (1.537 +/- A 0.746%), but the range of total alkaloid content in each species is so wide that the ranges of the three species greatly overlap. The contents of E, PE and ME are different among the three species. The ratio E/total alkaloid content and ratio E/PE as well as E and ME contents can be used for identification of E. sinica, E. intermedia and E. equisetina from one another.

语种: 英语
所属项目编号: 30425018
项目资助者: National Outstanding Youth Funds of China
WOS记录号: WOS:000291746900030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56246
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
3.Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

Recommended Citation:
Hong, Hao,Chen, Hu-Biao,Yang, Dong-Hui,et al. Comparison of contents of five ephedrine alkaloids in three official origins of Ephedra Herb in China by high-performance liquid chromatography[J]. JOURNAL OF NATURAL MEDICINES,2011,65(3-4):623-628.
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