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学科主题: 临床医学
题名:
The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow
作者: Li, Xiaohui; Du, Junbao; Jin, Hongfang; Tang, Xiuying; Bu, Dingfang; Tang, Chaoshu
关键词: hydrogen sulfide ; pulmonary vascular structure ; high pulmonary blood flow ; nitric oxide/nitric oxide synthase ; carbon monoxide/heme oxygenase
刊名: LIFE SCIENCES
发表日期: 2007-08-16
DOI: 10.1016/j.lfs.2007.07.021
卷: 81, 期:10, 页:841-849
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; SMOOTH-MUSCLE-CELLS ; CARBON-MONOXIDE ; PROLIFERATION ; NEUROMODULATOR ; HYPERTENSION ; PATHOGENESIS ; INHIBITOR ; SULFUR ; GROWTH
英文摘要:

The study aimed to explore the regulatory effect of endogenous hydrogen sulfide (H2S), a novel gasotransmitter, on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow. Thirty-two Sprague-Dawley rats were randomly divided into a sham group, shunt group, sham+PPG (propargylglycine, an inhibitor of cystathionine-gamma-lyase) group and shunt+PPG group. Rats in the shunt and shunt+PPG groups underwent abdominal aorta-inferior vena cava shunting. Rats in the shunt+PPG and sham+PPG groups were intraperitoneally injected with PPG. After 4 weeks of shunting, mean pulmonary artery pressure (MPAP) and pulmonary vascular structural remodeling (PVSR) were evaluated. H,S, nitric oxide (NO) and carbon monoxide (CO) contents were measured in lung tissues. Meanwhile, nitric oxide synthase (eNOS), heme oxygenase (HO-1) and proliferative cell nuclear antigen (PCNA) protein expressions and ERK activation were evaluated. After 4 weeks of shunting, rats showed PVSR with increased lung tissue H2S and NO content but decreased CO content. After the PPG treatment, MPAP further increased and PVSR was aggravated. Meanwhile, PCNA expression and ERK activation were augmented with decreased lung tissue CO and HO-I protein production but increased lung tissue NO production and eNOS expression. H,S exerted a protective effect on PVSR, and the inhibition of the NO/NOS pathway and the augmentation of the CO/HO pathway might be involved in the mechanisms by which H,S regulates PVSR in rats with high pulmonary flow. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000249636300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56253
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Ctr Lab, Beijing 100871, Peoples R China
3.Key Lab Mol Cardiovasc Sci, Ministry Educat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100871, Peoples R China

Recommended Citation:
Li, Xiaohui,Du, Junbao,Jin, Hongfang,et al. The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow[J]. LIFE SCIENCES,2007,81(10):841-849.
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