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学科主题: 临床医学
题名:
The risk of CIN II or greater in a one-year follow-up period in patients with ASC-H interpreted with cytology
作者: You, Ke; Guo, Yanli; Gen, Li; Qiao, Jie
关键词: Cervical cytological examination ; ASC-H ; Cervical intraepithelial neoplasia ; High-risk HPV
刊名: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
发表日期: 2010-04-01
DOI: 10.1016/j.ejogrb.2009.12.034
卷: 149, 期:2, 页:215-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: CERVICAL INTRAEPITHELIAL NEOPLASIA ; RANDOMIZED CONTROLLED-TRIAL ; ATYPICAL SQUAMOUS-CELLS ; CANNOT EXCLUDE ; CANCER ; LESIONS ; POPULATION ; WOMEN
英文摘要:

Objective: To explore the risk of CIN II or greater in patients with cytologically interpreted atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H) in a one-year follow-up period.

Study design: Patients with ASC-H accepted high-risk human papillomavirus (HPV) testing (Hybrid Capture II), colposcopy-directed biopsy, and endocervical curettage at baseline. Patients with CIN 1 or less were re-examined with cytology at 4-6-month intervals for up to 12 months only if the cytologic result was ASC-US or worse. Correlation between HPV infection at baseline and the follow-up results was analyzed using Chi-square statistical method and Fisher′s exact test.

Results: 34.0% (50/147) patients were diagnosed CIN II or greater at baseline. Four patients were diagnosed CIN II or greater at repeat colposcopy among the 65.0% (63/97) of patients who were diagnosed CIN I or less at baseline and had completed follow-up. The HPV positive rate was 61.9% (91/144) at baseline. The correlation coefficient of HPV negativity with CIN I or less was 100% (32/32).

Conclusions: The risk of CIN II or greater among patients with ASC-H was 40% and all patients (100%) with baseline negative HPV showed CIN I or less by cytology during the one-year follow-up period. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000276621400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56257
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
You, Ke,Guo, Yanli,Gen, Li,et al. The risk of CIN II or greater in a one-year follow-up period in patients with ASC-H interpreted with cytology[J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY,2010,149(2):215-217.
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