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学科主题: 临床医学
题名:
Comparison of efficacy of regional and extensive clinical target volumes in postoperative radiotherapy for esophageal squamous cell carcinoma
作者: Qiao, Xue-Ying3; Wang, Wei3; Zhou, Zhi-Guo3; Gao, Xian-Shu2; Chang, Joe Y.1
关键词: esophageal squamous cell carcinoma ; esophagectomy ; postoperative radiotherapy ; clinical target volume (CTV) ; survival
刊名: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
发表日期: 2008-02-01
DOI: 10.1016/j.ijrobp.2007.06.031
卷: 70, 期:2, 页:396-402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: RADIATION-THERAPY ; THORACIC ESOPHAGUS ; RADICAL ESOPHAGECTOMY ; CURATIVE RESECTION ; SURGERY ; CANCER ; LYMPHADENECTOMY ; SURVIVAL ; PATTERNS ; TRIAL
英文摘要:

Purpose: To compare and analyze the effect of different clinical target volumes (CTVs) on survival rate after postoperative radiotherapy (RT) for esophageal squamous cell carcinoma (SCC).

Methods and Materials: We studied 102 patients who underwent postoperative RT after radical resection for esophageal SCC (T3/4 or N1). The radiation dose was >= 50 Gy. In the extensive portal group (E group, 43 patients), the CTV encompassed the bilateral supraclavicular region, all mediastinal lymph nodes, the anastomosis site, and the left gastric and pericardial lymphatic. In the regional portal group (R group, 59 patients), the CTV was confined to tumor bed and the lymph nodes in the immediate region of the primary lesion. The 1-, 3-, and 5-year survival rates were compared between the groups, and multivariate/univariate analysis for factors predicting survival was studied.

Results: For the entire group, the 1-, 3- and 5-year survival rates were 76.3%, 50.5%, and 42.9%, respectively (median survival, 30 months). The 1-, 3-, and 5-year survival rates were 76.5%, 52.1%, and 41.3%, respectively, in the E group and 76.2%, 49.2%, and 44.6%, respectively, in the R group (not significant). According to the multivariate analysis, N stage, number of lymph nodes with metastatic disease, and tumor length were the independent prognostic factors for survival.

Conclusions: Using a regional portal in postoperative RT for esophageal SCC is not associated with compromised survival compared with extensive portal RT and therefore should be considered. N stage, number of affected lymph nodes, and tumor length predict poor survival. (C) 2008 Elsevier Inc.

语种: 英语
WOS记录号: WOS:000252521700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56258
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Univ Texas Houston, MD Anderson Canc Ctr, Dept Thorac Radiat Oncol, Unit 97, Houston, TX 77030 USA
2.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100871, Peoples R China
3.Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang, Peoples R China

Recommended Citation:
Qiao, Xue-Ying,Wang, Wei,Zhou, Zhi-Guo,et al. Comparison of efficacy of regional and extensive clinical target volumes in postoperative radiotherapy for esophageal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2008,70(2):396-402.
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