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IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学血液病研究所  > 期刊论文
学科主题: 临床医学
题名:
Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation
作者: Lv, Meng1; Ye, Hai-ge1,2; Zhao, Xiao-su1; Zhao, Xiang-yu1; Chang, Ying-jun1; Liu, Dai-hong1; Xu, Lan-ping1; Huang, Xiao-jun1
刊名: PLOS ONE
发表日期: 2013-03-07
DOI: 10.1371/journal.pone.0058735
卷: 8, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: VERSUS-HOST-DISEASE ; ACUTE-PHASE PROTEINS ; MARROW ; BLOOD ; GVHD ; OXIDASE ; TRIALS ; SERUM
英文摘要:

Acute graft-versus-host-disease (aGvHD) is the major cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, diagnostic biomarkers for aGvHD have been shown to play important roles in evaluating disease status and mortality risk after allo-HSCT. To identify plasma biomarkers for aGvHD with high sensitivity and specificity, a quantitative proteomic approach using 8-plex isobaric tags for relative and absolute quantitation (8-plex iTRAQ) was employed to screen differentially expressed proteins in peripheral blood before and after the onset of aGvHD. Four target proteins, ceruloplasmin (CP), myeloperoxidase (MPO), complement factor H (CFH), and alpha-1-acid glycoprotein (AGP), were chosen for preliminary validation with enzyme linked immunosorbent assay (ELISA) in 20 paired samples at both the time of diagnosis of aGvHD and the time of complete response. The most promising candidate, ceruloplasmin, was further validated at fixed time points after allo-HSCT and during aGvHD. The plasma ceruloplasmin levels were significantly increased during the period of aGvHD onset and were markedly decreased as aGvHD resolved. The plasma ceruloplasmin levels at different time points post-transplant in the aGvHD (+) group were significantly higher than those in the aGvHD (2) group (p<0.001). The elevation of ceruloplasmin level in patients with active aGvHD was independent of infection status. Patients whose ceruloplasmin levels were elevated above 670 mu g/ml at 7, 14 and 21 days after allo-HSCT had a remarkably increased probability of subsequently developing aGvHD. In conclusion, our results suggest that plasma ceruloplasmin is a potential plasma biomarker of aGvHD, and it also has prognostic value for risk-adapted prophylaxis during the consecutive time points monitored in the first month after allo-HSCT.

语种: 英语
所属项目编号: 81230013 ; 2013CB733700 ; Z111107067311070 ; 7122193
项目资助者: Key Program of National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Beijing Municipal Science and Technology Program ; Natural Science Foundation of Beijing
WOS记录号: WOS:000318334500121
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56260
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

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作者单位: 1.Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou, Zhejiang, Peoples R China

Recommended Citation:
Lv, Meng,Ye, Hai-ge,Zhao, Xiao-su,et al. Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation[J]. PLOS ONE,2013,8(3).
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