学科主题临床医学
Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation
Lv, Meng1; Ye, Hai-ge1,2; Zhao, Xiao-su1; Zhao, Xiang-yu1; Chang, Ying-jun1; Liu, Dai-hong1; Xu, Lan-ping1; Huang, Xiao-jun1
刊名PLOS ONE
2013-03-07
DOI10.1371/journal.pone.0058735
8期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Key Program of National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Beijing Municipal Science and Technology Program ; Natural Science Foundation of Beijing ; Key Program of National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Beijing Municipal Science and Technology Program ; Natural Science Foundation of Beijing
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]VERSUS-HOST-DISEASE ; ACUTE-PHASE PROTEINS ; MARROW ; BLOOD ; GVHD ; OXIDASE ; TRIALS ; SERUM
英文摘要

Acute graft-versus-host-disease (aGvHD) is the major cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, diagnostic biomarkers for aGvHD have been shown to play important roles in evaluating disease status and mortality risk after allo-HSCT. To identify plasma biomarkers for aGvHD with high sensitivity and specificity, a quantitative proteomic approach using 8-plex isobaric tags for relative and absolute quantitation (8-plex iTRAQ) was employed to screen differentially expressed proteins in peripheral blood before and after the onset of aGvHD. Four target proteins, ceruloplasmin (CP), myeloperoxidase (MPO), complement factor H (CFH), and alpha-1-acid glycoprotein (AGP), were chosen for preliminary validation with enzyme linked immunosorbent assay (ELISA) in 20 paired samples at both the time of diagnosis of aGvHD and the time of complete response. The most promising candidate, ceruloplasmin, was further validated at fixed time points after allo-HSCT and during aGvHD. The plasma ceruloplasmin levels were significantly increased during the period of aGvHD onset and were markedly decreased as aGvHD resolved. The plasma ceruloplasmin levels at different time points post-transplant in the aGvHD (+) group were significantly higher than those in the aGvHD (2) group (p<0.001). The elevation of ceruloplasmin level in patients with active aGvHD was independent of infection status. Patients whose ceruloplasmin levels were elevated above 670 mu g/ml at 7, 14 and 21 days after allo-HSCT had a remarkably increased probability of subsequently developing aGvHD. In conclusion, our results suggest that plasma ceruloplasmin is a potential plasma biomarker of aGvHD, and it also has prognostic value for risk-adapted prophylaxis during the consecutive time points monitored in the first month after allo-HSCT.

语种英语
所属项目编号81230013 ; 2013CB733700 ; Z111107067311070 ; 7122193
资助者Key Program of National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Beijing Municipal Science and Technology Program ; Natural Science Foundation of Beijing ; Key Program of National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Beijing Municipal Science and Technology Program ; Natural Science Foundation of Beijing
WOS记录号WOS:000318334500121
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56260
专题北京大学第二临床医学院_北京大学血液病研究所
作者单位1.Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou, Zhejiang, Peoples R China
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GB/T 7714
Lv, Meng,Ye, Hai-ge,Zhao, Xiao-su,et al. Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation[J]. PLOS ONE,2013,8(3).
APA Lv, Meng.,Ye, Hai-ge.,Zhao, Xiao-su.,Zhao, Xiang-yu.,Chang, Ying-jun.,...&Huang, Xiao-jun.(2013).Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation.PLOS ONE,8(3).
MLA Lv, Meng,et al."Ceruloplasmin Is a Potential Biomarker for aGvHD following Allogeneic Hematopoietic Stem Cell Transplantation".PLOS ONE 8.3(2013).
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