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学科主题: 口腔医学
题名:
Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration
作者: Wei, Jie3,4; Jia, Junfeng3,4; Wu, Fan3,4; Wei, Shicheng1,2,6; Zhou, Huanjun3,4; Zhang, Hongbo3,4; Shin, Jung-Woog5; Liu, Changsheng3,4
关键词: Hierarchically porous scaffolds ; Magnesium calcium phosphate ; Biodegradability ; Biocompatibility ; Bone generation
刊名: BIOMATERIALS
发表日期: 2010-02-01
DOI: 10.1016/j.biomaterials.2009.11.005
卷: 31, 期:6, 页:1260-1269
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: IN-VITRO ; COMPOSITE SCAFFOLD ; CEMENT ; CELLS ; DIFFERENTIATION ; INGROWTH ; HYDROXYAPATITE ; PROLIFERATION ; IMPLANTATION ; ADHESION
英文摘要:

Hierarchically 3D microporous/macroporous magnesium-calcium phosphate (micro/ma-MCP) scaffolds containing magnesium ammonium phosphate hexahydrate [NH(4)MgPO(4)center dot 6H(2)O] and hydroxyapatite [Ca(10)(PO(4))(6)(CH)(2)] were fabricated from cement utilizing leaching method in the presence of sodium chloride (NaCl) particles and NaCl saturated water solution. NaCl particles produced macropororosity, and NaCl solution acted as both cement liquid and porogens, inducing the formation of microporosity. The micro/ma-MCP scaffolds with porosities varied from 52 to 78% showed well interconnected and open macropores with the sizes of 400-500 mu m, and degradation of the scaffolds was significantly enhanced in Tris-HCl solution compared with macroporous MCP (ma-MCP) and corresponding calcium phosphate cement (CPC) scaffolds. Cell attachment and proliferation of MG(63) on micro/ma-MCP were significantly better than ma-MCP and CPC scaffolds because of the presence of microporosity, which enhanced the surface area of the scaffolds. Moreover, the alkaline phosphatase (ALP) activity of the MG(63) cells on micro/ma-MCP was significantly higher than ma-MCP and CPC scaffolds at 7 days, and the MG(63) cells with normal phenotype spread well and formed confluent layers across the macroporous walls of the microlma-MCP scaffolds. Histological evaluation confirmed that the micro/ma-MCP scaffolds improved the efficiency of new bone regeneration, and exhibited excellent biocompatibility, biodegradability and faster and more effective osteogenesis in vivo. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30970720 ; 0852nm02700 ; 08DZ0501600 ; 2007CB936103
项目资助者: National Natural Science Funds of China ; Nano special program of Science and Technology Development of Shanghai ; Standard Special program of Science and Technology Development of Shanghai ; 973Project of the Ministry of Science and Technology of the People&prime ; s Republic of China ; Shanghai Pujiang Program (2008)
WOS记录号: WOS:000273985100027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56263
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China
3.E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China
4.E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China
5.Inje Univ, Dept Biomed Engn, Res Grp 1, BK 21, Gimhae 621749, South Korea
6.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

Recommended Citation:
Wei, Jie,Jia, Junfeng,Wu, Fan,et al. Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration[J]. BIOMATERIALS,2010,31(6):1260-1269.
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