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学科主题: 临床医学
题名:
Identification and Characterization of Xlr5c as a Novel Nuclear Localization Protein in Mouse Germ Cells
作者: Zhuang, Xin-Jie1; Tang, Wen-hao2; Liu, Chang-yu1; Zhu, Jin-liang1; Feng, Xue1; Yan, Jie1; Lian, Ying1; Liu, Ping1; Qiao, Jie1
刊名: PLOS ONE
发表日期: 2015-06-15
DOI: 10.1371/journal.pone.0130087
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENE FAMILY XLR ; HISTONE ACETYLTRANSFERASE ; COGNITIVE FUNCTION ; EXPRESSION ; INTERACTS ; SYNAPSIS ; SEQUENCE ; ENCODES ; ELEMENT ; MICE
英文摘要:

Background

Spermatogenesis is the complex process by which diploid stem cells generate haploid germ cells in gamete production. Members of the Xlr (X-chromosome linked, lymphocyte regulated) superfamily play essential roles in spermatogenesis. The expression, localization and role in spermatogenesis of one such member, Xlr5c, has not been reported previously.

Methodology/Principal Findings

Xlr5c mRNA and protein levels in murine testes and other tissues were investigated using RT-PCR and Western blotting. Xlr5c was abundantly transcribed in mouse testes, particularly during the early stages of spermatogenesis and throughout prophase I in the nuclei of spermatocytes. Xlr5c was specifically localized at synaptonemal complexes(SCs) region in preleptotene and pachytene spermatocytes, as was the homologous Xlr protein Sycp3.

Conclusions/Significance

These results suggest that Xlr5c was abundantly transcribed in germ cells, localized at SCs region, where it may play a potential role during the early stages of spermatogenesis. Identification and characterization of this novel testis protein may offer a new perspective for understanding of the molecular mechanisms involved in germ cell differentiation.

语种: 英语
所属项目编号: 81200466 ; 81300483 ; 31401256 ; 81200470 ; 81070534
项目资助者: National Natural Science Foundation of China for Young Scholars ; National Natural Science Foundation of China
WOS记录号: WOS:000356329900137
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56279
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med,Dept Obstet & Gynecol, Key Lab Assisted Reprod,Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Zhuang, Xin-Jie,Tang, Wen-hao,Liu, Chang-yu,et al. Identification and Characterization of Xlr5c as a Novel Nuclear Localization Protein in Mouse Germ Cells[J]. PLOS ONE,2015,10(6).
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