IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection
Shao, Y.1,2; Zhang, W.1,3,4; Dong, X.1; Liu, W.1; Zhang, Ch.1; Zhang, J.2; Zhong, Q.2; Wu, Q.1; Yang, H.1,2; Chen, Y.3; Wan, J.1,4; Yu, B.1,2
关键词Herpes Simplex Virus Type 2 Keratinocytes Cytokines Immunity
刊名ACTA VIROLOGICA
2010
DOI10.4149/av_2010_04_261
54期:4页:261-267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; TOLL-LIKE RECEPTOR-2 ; HUMAN EPIDERMAL-KERATINOCYTES ; DNA ENCODING IFN-ALPHA-1 ; ALPHA-BETA INTERFERON ; TLR EXPRESSION ; PROTECTS MICE ; TNF-ALPHA ; RECOMBINANT ; CELLS
英文摘要

Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcerative disease in the developed world. Keratinocytes are the primary cells involved in clinical lesions caused by HSV-2. In our study, we intensively examined cytokine expression in the HSV-2-infected keratinocytes. We observed upregulation of a series of cytokines including early-induced antiviral cytokines as interferons alpha, beta (IFN-alpha, beta), tumor necrosis factor a (TNF-alpha), colony stimulating factors (CSFs) as G-CSF, GM-CSF, interleukin 3 (IL-3), growth factors (EGF, KGF, and IGF-beta 1), defensins, selectins, leukocyte function-associated antigens (LFAs,) and toll-like receptors (TLR-2, 3, 4, and 9). More importantly, we found that HSV-2-infected keratinocytes stimulated the proliferation of lymphocytes in co-cultivation system. These data suggest that keratinocytes participate in the immune response to HSV-2 infection in two ways. They secrete inflammatory cytokines to resist the HSV-2 infection directly and recruit the immune cells to eliminate the primary infection indirectly and enhance the adaptive immunity to prevent subsequent infections.

语种英语
WOS记录号WOS:000293877800004
资助机构Shenzhen Science and Technology Project
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56280
专题北京大学深圳医院
北京大学第二临床医学院_呼吸科
北京大学临床肿瘤学院_内镜中心
作者单位1.Peking Univ, Shenzhen Hosp, Beijing, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen, Guangdong, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Jinan, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Shao, Y.,Zhang, W.,Dong, X.,et al. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection[J]. ACTA VIROLOGICA,2010,54(4):261-267.
APA Shao, Y..,Zhang, W..,Dong, X..,Liu, W..,Zhang, Ch..,...&Yu, B..(2010).Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection.ACTA VIROLOGICA,54(4),261-267.
MLA Shao, Y.,et al."Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection".ACTA VIROLOGICA 54.4(2010):261-267.
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