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学科主题: 临床医学
题名:
Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis
作者: Jiao, Guangjun; Ren, Tingting; Lu, Qunshan; Sun, Yifeng; Lou, Zhiyuan; Peng, Xianbo; Liang, Weimin; Guo, Wei
关键词: Cyclooxygenase-2 ; Osteosarcoma ; Metastasis ; Clinical stage ; Survival
刊名: TUMOR BIOLOGY
发表日期: 2013-10-01
DOI: 10.1007/s13277-013-0998-2
卷: 34, 期:5, 页:2489-2495
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SINGLE INSTITUTION ; CERVICAL-CANCER ; EXPRESSION ; SURVIVAL ; INHIBITORS ; COX-2
英文摘要:

Published studies researching the prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The pooled odds ratios (ORs) or hazard ratios (HRs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the effects. Fourteen studies with 735 osteosarcoma patients were included to estimate the relationship between COX-2 and metastasis of tumor, clinical stage, and 3-year overall survival. High expressions of COX-2 predicted neoplasm metastasis (OR = 1.891, 95 % CI 1.276-2.803, P = 0.002), advanced clinical stage (OR = 1.801, 95 % CI 1.257-2.581, P = 0.001). In addition, high COX-2 expression tended to be associated with a poor 3-year survival (HR = 1.741, 95 % CI 0.762-3.979, P = 0.188), but the difference was not significant. Therefore, this meta-analysis demonstrated that high COX-2 expression might be an unfavorable prognostic effect in osteosarcoma.

语种: 英语
所属项目编号: Z11110705881102
项目资助者: Beijing Municipal Science and Technology Planning Project
WOS记录号: WOS:000325079200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56283
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ, Musculoskeletal Tumor Ctr, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Jiao, Guangjun,Ren, Tingting,Lu, Qunshan,et al. Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis[J]. TUMOR BIOLOGY,2013,34(5):2489-2495.
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