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学科主题临床医学
Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis
Jiao, Guangjun; Ren, Tingting; Lu, Qunshan; Sun, Yifeng; Lou, Zhiyuan; Peng, Xianbo; Liang, Weimin; Guo, Wei
关键词Cyclooxygenase-2 Osteosarcoma Metastasis Clinical Stage Survival
刊名TUMOR BIOLOGY
2013-10-01
DOI10.1007/s13277-013-0998-2
34期:5页:2489-2495
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SINGLE INSTITUTION ; CERVICAL-CANCER ; EXPRESSION ; SURVIVAL ; INHIBITORS ; COX-2
英文摘要

Published studies researching the prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The pooled odds ratios (ORs) or hazard ratios (HRs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the effects. Fourteen studies with 735 osteosarcoma patients were included to estimate the relationship between COX-2 and metastasis of tumor, clinical stage, and 3-year overall survival. High expressions of COX-2 predicted neoplasm metastasis (OR = 1.891, 95 % CI 1.276-2.803, P = 0.002), advanced clinical stage (OR = 1.801, 95 % CI 1.257-2.581, P = 0.001). In addition, high COX-2 expression tended to be associated with a poor 3-year survival (HR = 1.741, 95 % CI 0.762-3.979, P = 0.188), but the difference was not significant. Therefore, this meta-analysis demonstrated that high COX-2 expression might be an unfavorable prognostic effect in osteosarcoma.

语种英语
WOS记录号WOS:000325079200003
项目编号Z11110705881102
资助机构Beijing Municipal Science and Technology Planning Project
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56283
专题北京大学第二临床医学院_骨肿瘤科
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位Peking Univ, Musculoskeletal Tumor Ctr, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
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Jiao, Guangjun,Ren, Tingting,Lu, Qunshan,et al. Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis[J]. TUMOR BIOLOGY,2013,34(5):2489-2495.
APA Jiao, Guangjun.,Ren, Tingting.,Lu, Qunshan.,Sun, Yifeng.,Lou, Zhiyuan.,...&Guo, Wei.(2013).Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis.TUMOR BIOLOGY,34(5),2489-2495.
MLA Jiao, Guangjun,et al."Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis".TUMOR BIOLOGY 34.5(2013):2489-2495.
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