北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis
作者: Jiao, Guangjun; Ren, Tingting; Lu, Qunshan; Sun, Yifeng; Lou, Zhiyuan; Peng, Xianbo; Liang, Weimin; Guo, Wei
关键词: Cyclooxygenase-2 ; Osteosarcoma ; Metastasis ; Clinical stage ; Survival
刊名: TUMOR BIOLOGY
发表日期: 2013-10-01
DOI: 10.1007/s13277-013-0998-2
卷: 34, 期:5, 页:2489-2495
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SINGLE INSTITUTION ; CERVICAL-CANCER ; EXPRESSION ; SURVIVAL ; INHIBITORS ; COX-2
英文摘要:

Published studies researching the prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The pooled odds ratios (ORs) or hazard ratios (HRs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the effects. Fourteen studies with 735 osteosarcoma patients were included to estimate the relationship between COX-2 and metastasis of tumor, clinical stage, and 3-year overall survival. High expressions of COX-2 predicted neoplasm metastasis (OR = 1.891, 95 % CI 1.276-2.803, P = 0.002), advanced clinical stage (OR = 1.801, 95 % CI 1.257-2.581, P = 0.001). In addition, high COX-2 expression tended to be associated with a poor 3-year survival (HR = 1.741, 95 % CI 0.762-3.979, P = 0.188), but the difference was not significant. Therefore, this meta-analysis demonstrated that high COX-2 expression might be an unfavorable prognostic effect in osteosarcoma.

语种: 英语
所属项目编号: Z11110705881102
项目资助者: Beijing Municipal Science and Technology Planning Project
WOS记录号: WOS:000325079200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56283
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Musculoskeletal Tumor Ctr, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Jiao, Guangjun,Ren, Tingting,Lu, Qunshan,et al. Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis[J]. TUMOR BIOLOGY,2013,34(5):2489-2495.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jiao, Guangjun]'s Articles
[Ren, Tingting]'s Articles
[Lu, Qunshan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jiao, Guangjun]‘s Articles
[Ren, Tingting]‘s Articles
[Lu, Qunshan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace