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IR@PKUHSC  > 北京大学口腔医学院  > 第二门诊部  > 期刊论文
学科主题: 口腔医学
题名:
Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation
作者: Li, Qing1,2; Zhou, Gang1; Wang, Tong2; Hou, Yongzhao1; Deng, Xuliang3; Wei, Yan3
刊名: JOURNAL OF NANOMATERIALS
发表日期: 2015
DOI: 10.1155/2015/835604
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MESENCHYMAL STEM-CELLS ; STRUCTURAL-CHARACTERIZATION ; OSTEOGENIC DIFFERENTIATION ; BONE-MARROW ; IN-VITRO ; HYDROXYAPATITE ; EXPOSURE ; FIELDS ; SCAFFOLDS ; MAGNETORECEPTION
英文摘要:

Regenerative medicine consisting of cells and materials offers a new approach for repairing and regenerating the organs and tissues. More and more researches focused on the magnetic nanobiomaterials due to its superior advantages to traditional materials. However, the toxicity of nanosized magnetic particles cannot be ignored, especially under the magnetic situation. This study aims to study the biocompatibility of nanohydroxyapatite (n-HA-) coated magnetic nanoparticles under the magnetic situation. n-HA-coated magnetic nanoparticles were fabricated through an ultrasound-assisted coprecipitation method. Subsequently, these materials were analyzed by transmission electron microscope (TEM) and X-ray diffraction (XRD) and then were cultured with mesenchyme stem cells derived from human bone marrow (hMSC-BM). In vitro experiment proved the satisfactory biocompatibility of n-HA-coated magnetic nanoparticles. These important factors (ALP, OCN, and OPN) influence the osteogenic differentiation of hMSC-BM. It was found that the hMSC-BM with combination of n-HA/Fe3O4 and magnetic stimulation presented higher degree of osteoblast-related markers than that in each alone. This research demonstrated that a novel nanohydroxyapatite coated magnetic nanoparticle is safe under the magnetic situation. Therefore, these n-HA-coated magnetic nanoparticles are promising biomagnetic materials for future applications.

语种: 英语
所属项目编号: 81171000 ; 31100666 ; 11120101001 ; 61227902 ; 11172031 ; 10925208 ; 51302005 ; 2012AA022501 ; Z121100005212009 ; 2011DFA32190 ; 2011CB710901 ; 2012CB933900 ; 2012BAI18B06 ; 2012BAI18B05 ; 2012BAI07B01 ; B13003 ; 20130001120112
项目资助者: National Natural Science Foundation of China (NSFC) ; National High Technology Research and Development Program of China ; Science Foundation of Beijing Research Grant ; Key International S&amp ; T Cooperation Project ; National Basic Research Programof China (973 program) ; National Key Technology RD Program ; 111 Project of China ; International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China ; Doctoral Scientific Fund Project of the Ministry of Education of China ; Fundamental Research Funds for the Central Universities of China ; Peking University-Tsinghua University Joint Center for Life Sciences
WOS记录号: WOS:000355439500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56287
Appears in Collections:北京大学口腔医学院_第二门诊部_期刊论文

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作者单位: 1.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
2.Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Li, Qing,Zhou, Gang,Wang, Tong,et al. Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation[J]. JOURNAL OF NANOMATERIALS,2015.
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