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学科主题口腔医学
Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation
Li, Qing1,2; Zhou, Gang1; Wang, Tong2; Hou, Yongzhao1; Deng, Xuliang3; Wei, Yan3
刊名JOURNAL OF NANOMATERIALS
2015
DOI10.1155/2015/835604
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]MESENCHYMAL STEM-CELLS ; STRUCTURAL-CHARACTERIZATION ; OSTEOGENIC DIFFERENTIATION ; BONE-MARROW ; IN-VITRO ; HYDROXYAPATITE ; EXPOSURE ; FIELDS ; SCAFFOLDS ; MAGNETORECEPTION
英文摘要

Regenerative medicine consisting of cells and materials offers a new approach for repairing and regenerating the organs and tissues. More and more researches focused on the magnetic nanobiomaterials due to its superior advantages to traditional materials. However, the toxicity of nanosized magnetic particles cannot be ignored, especially under the magnetic situation. This study aims to study the biocompatibility of nanohydroxyapatite (n-HA-) coated magnetic nanoparticles under the magnetic situation. n-HA-coated magnetic nanoparticles were fabricated through an ultrasound-assisted coprecipitation method. Subsequently, these materials were analyzed by transmission electron microscope (TEM) and X-ray diffraction (XRD) and then were cultured with mesenchyme stem cells derived from human bone marrow (hMSC-BM). In vitro experiment proved the satisfactory biocompatibility of n-HA-coated magnetic nanoparticles. These important factors (ALP, OCN, and OPN) influence the osteogenic differentiation of hMSC-BM. It was found that the hMSC-BM with combination of n-HA/Fe3O4 and magnetic stimulation presented higher degree of osteoblast-related markers than that in each alone. This research demonstrated that a novel nanohydroxyapatite coated magnetic nanoparticle is safe under the magnetic situation. Therefore, these n-HA-coated magnetic nanoparticles are promising biomagnetic materials for future applications.

语种英语
WOS记录号WOS:000355439500001
项目编号81171000 ; 31100666 ; 11120101001 ; 61227902 ; 11172031 ; 10925208 ; 51302005 ; 2012AA022501 ; Z121100005212009 ; 2011DFA32190 ; 2011CB710901 ; 2012CB933900 ; 2012BAI18B06 ; 2012BAI18B05 ; 2012BAI07B01 ; B13003 ; 20130001120112
资助机构National Natural Science Foundation of China (NSFC) ; National High Technology Research and Development Program of China ; Science Foundation of Beijing Research Grant ; Key International S&amp ; T Cooperation Project ; National Basic Research Programof China (973 program) ; National Key Technology RD Program ; 111 Project of China ; International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China ; Doctoral Scientific Fund Project of the Ministry of Education of China ; Fundamental Research Funds for the Central Universities of China ; Peking University-Tsinghua University Joint Center for Life Sciences
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56287
专题北京大学口腔医学院_第二门诊部
北京大学口腔医学院_特诊科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
2.Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Li, Qing,Zhou, Gang,Wang, Tong,et al. Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation[J]. JOURNAL OF NANOMATERIALS,2015.
APA Li, Qing,Zhou, Gang,Wang, Tong,Hou, Yongzhao,Deng, Xuliang,&Wei, Yan.(2015).Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation.JOURNAL OF NANOMATERIALS.
MLA Li, Qing,et al."Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation".JOURNAL OF NANOMATERIALS (2015).
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