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学科主题: 临床医学
题名:
Immunoregulatory effects of a glucogalactan from the root of Panax quinquefolium L.
作者: Zhu, Wenjing1; Han, Bo2; Sun, Yun3; Wang, Zhenyu4; Yang, Xiuhua1
关键词: Panax quinquefolium ; Glucogalactan ; Anti-Lewis lung carcinoma ; Immunoregulatory effects
刊名: CARBOHYDRATE POLYMERS
发表日期: 2012-03-01
DOI: 10.1016/j.carbpol.2011.11.066
卷: 87, 期:4, 页:2725-2729
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Chemistry ; Polymer Science
关键词[WOS]: WATER-SOLUBLE POLYSACCHARIDE ; LUNG-CANCER ; IN-VIVO ; GINSENG ; EXTRACT ; CELLS ; MICE
英文摘要:

In this research we purified one homogeneous glucogalactan from the roots of Panax quinquefolium, with a molecular weight of 54 kDa estimated by high-performance gel permeation chromatography (HPGPC). The monosaccharide composition of PPQ was composed of Glc (glucose) and Gal (galactose) in a molar ratio of 2.1:1, as determined by gas chromatography (GC). In order to evaluate the anti-lung carcinoma and immunoregulatory effects of this glucogalactan in mice, we established a Lewis lung carcinoma model in C57BL/6 mouse. The results showed that PPQ not only could inhibit the growth of lung tumor, but also enhance the thymus and spleen indices, as well as the level of IFN-gamma, IL-10 and IL-2, indicating PPQ could have a possible cancer therapeutic potential. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000299969800051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56292
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Shenyang Med Coll, Sch Publ Hlth, Shenyang 110034, Peoples R China
2.Harbin Med Coll, Affiliated Hosp 1, Abdominal Ultrasound Dept, Harbin 150001, Peoples R China
3.Harbin Med Coll, Affiliated Hosp 1, Dept Oncol, Harbin 150001, Peoples R China
4.Peking Univ, Affiliated Hosp 3, Resp Dept, Beijing 100191, Peoples R China

Recommended Citation:
Zhu, Wenjing,Han, Bo,Sun, Yun,et al. Immunoregulatory effects of a glucogalactan from the root of Panax quinquefolium L.[J]. CARBOHYDRATE POLYMERS,2012,87(4):2725-2729.
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