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学科主题: 基础医学
题名:
Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse
作者: Yu, Yanrong1,2; Wang, Yun; Feng, Meifu1
关键词: HLA-G1 ; natural killer cells ; cytotoxicity ; signal transduction ; immunosynapse
刊名: HUMAN IMMUNOLOGY
发表日期: 2008
DOI: 10.1016/j.humimm.2007.11.005
卷: 69, 期:1, 页:16-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: NK-CELL CYTOTOXICITY ; HLA-G EXPRESSION ; G MESSENGER-RNA ; CLASS-I ; HUMAN TROPHOBLASTS ; FUNCTIONAL-ROLE ; VAV PROTEINS ; RECEPTOR ; IDENTIFICATION ; CYTOSKELETON
英文摘要:

Nonclassical major histocompatibility complex (MHC) class I molecule human leukocyte antigen (HLA)-G is normally expressed on the placental. cells, especially fetal. endothetial. cells and invasive cytotrophoblast cells at the maternal-fetal interface. This antigen meditates immune tolerance in pregnancy through interaction with immune cells including natural killer (NK) cells. In this study, we investigated the mechanisms underlying HLA-G1-mediated inhibition of NK cytotoxicity using HLA-G1-transfected K562 cells and NK92 cells. We found that inhibition of NK cytotoxicity by HLA-G1 was associated with decreased formation of NK-target cell conjugates and defective formation of immunologic synapse, as characterized by actin depolarization and perforin immobilization in nonactive NK cells. HLA-G1 engagement induced dephosphorylation of Vav by tyrosine phosphatase-1 (SHP-1), and thus blocked the Syk -> MEK/ERK activating signaling pathway in activating NK cells. These results indicate that HLA-G1 inhibits NK cytotoxicity by Mocking activating signal transduction pathway, which is required for the formation of activating immunologic synapse. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000253670300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56294
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Med Parasitol, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Yanrong,Wang, Yun,Feng, Meifu. Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse[J]. HUMAN IMMUNOLOGY,2008,69(1):16-23.
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