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Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse
Yu, Yanrong1,2; Wang, Yun; Feng, Meifu1
关键词Hla-g1 Natural Killer Cells Cytotoxicity Signal Transduction Immunosynapse
刊名HUMAN IMMUNOLOGY
2008
DOI10.1016/j.humimm.2007.11.005
69期:1页:16-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]NK-CELL CYTOTOXICITY ; HLA-G EXPRESSION ; G MESSENGER-RNA ; CLASS-I ; HUMAN TROPHOBLASTS ; FUNCTIONAL-ROLE ; VAV PROTEINS ; RECEPTOR ; IDENTIFICATION ; CYTOSKELETON
英文摘要

Nonclassical major histocompatibility complex (MHC) class I molecule human leukocyte antigen (HLA)-G is normally expressed on the placental. cells, especially fetal. endothetial. cells and invasive cytotrophoblast cells at the maternal-fetal interface. This antigen meditates immune tolerance in pregnancy through interaction with immune cells including natural killer (NK) cells. In this study, we investigated the mechanisms underlying HLA-G1-mediated inhibition of NK cytotoxicity using HLA-G1-transfected K562 cells and NK92 cells. We found that inhibition of NK cytotoxicity by HLA-G1 was associated with decreased formation of NK-target cell conjugates and defective formation of immunologic synapse, as characterized by actin depolarization and perforin immobilization in nonactive NK cells. HLA-G1 engagement induced dephosphorylation of Vav by tyrosine phosphatase-1 (SHP-1), and thus blocked the Syk -> MEK/ERK activating signaling pathway in activating NK cells. These results indicate that HLA-G1 inhibits NK cytotoxicity by Mocking activating signal transduction pathway, which is required for the formation of activating immunologic synapse. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000253670300004
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56294
专题北京大学基础医学院
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Med Parasitol, Beijing 100871, Peoples R China
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GB/T 7714
Yu, Yanrong,Wang, Yun,Feng, Meifu. Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse[J]. HUMAN IMMUNOLOGY,2008,69(1):16-23.
APA Yu, Yanrong,Wang, Yun,&Feng, Meifu.(2008).Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse.HUMAN IMMUNOLOGY,69(1),16-23.
MLA Yu, Yanrong,et al."Human leukocyte antigen-G1 inhibits natural killer cytotoxicity through blocking the activating signal transduction pathway and formation of activating immunologic synapse".HUMAN IMMUNOLOGY 69.1(2008):16-23.
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