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学科主题: 精神卫生
题名:
The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: A double-blind placebo-controlled trial
作者: Zhang, XY; Zhou, DF; Cao, LY; Xu, CQ; Chen, DC; Wu, GY
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2004-02-01
DOI: 10.1097/01.jcp.0000104912.75206.2b
卷: 24, 期:1, 页:83-86
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: POSSIBLE INVOLVEMENT ; SCHIZOPHRENIA ; RADICALS
英文摘要:

Free radicals may be involved in the pathogenesis of tardive dyskinesia (TD). Vitamin E, a free radical scavenger, has been reported to improve symptoms of TD. The present study was designed to replicate this finding in a group of Chinese patients with TD, and to examine the effect of vitamin E treatment on blood superoxide dismutase (SOD), a critical enzyme in the detoxification of free radicals. Forty-one inpatients with TD completed a double-blind, placebo-controlled, parallel-group study of vitamin E. Twenty-two of the patients were randomly assigned to receive a fixed dose of 1200 IU/d vitamin E, and 19 were assigned to a placebo for 12 weeks. Patients were assessed primarily using the Abnormal Involuntary Movement Scale (AIMS) at baseline, weeks 6 and 12. Blood SOD levels were measured by radioimmunometric assay before and after treatment. The results showed that the reduction in AIMS score from baseline was significantly higher with vitamin E treatment compared with placebo (45.9% vs. 4.3%). Blood SOD levels were significantly increased after treatment with vitamin E (P = 0.001), but no change with placebo treatment (P < 0.05). These results support earlier findings of the efficacy of vitamin E in the treatment of TD. Moreover, the efficacy of vitamin E may be due to its ability to increase SOD level, which may reduce oxidative injure in tardive dyskinesia.

语种: 英语
WOS记录号: WOS:000188093400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56296
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Dept Psychiat,Abraham Ribicoff Res Facil, New Haven, CT 06508 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China

Recommended Citation:
Zhang, XY,Zhou, DF,Cao, LY,et al. The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: A double-blind placebo-controlled trial[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2004,24(1):83-86.
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