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Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation
Zhao, Xiang-Yu1; Chang, Ying-Jun1; Zhao, Xiao-Su1; Xu, Lan-Ping1; Zhang, Xiao-Hui1; Liu, Kai-Yan1; Li, Dan1; Huang, Xiao-Jun1,2
关键词Kir Haploidentica Hsct Nk Cells T-cell Replete Leukemia
刊名EUROPEAN JOURNAL OF IMMUNOLOGY
2015-08-01
DOI10.1002/eji.201445057
45期:8页:2396-2408
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]NATURAL-KILLER-CELLS ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; ACUTE MYELOID-LEUKEMIA ; CLASS-I MOLECULES ; CYTOMEGALOVIRUS-INFECTION ; MARROW TRANSPLANTATION ; HEMATOPOIETIC TRANSPLANTS ; RECEPTOR EXPRESSION ; CLINICAL-OUTCOMES ; EFFECTOR FUNCTION
英文摘要

Natural killer (NK) cells that express self-HLA-specific receptors (where HLA is human leukocyte antigen) are "licensed" and more readily activated than unlicensed cells; therefore, NK-cell licensing could influence the antileukemia effects of NK cells following haploidentical stem cell transplantation (haplo-SCT). In this study, we compared the functionality of reconstituting NK cells, based on CD107 alpha expression and interferon-ysecretion, in a cohort of 29 patients that expressed (n = 8) or lacked (n = 21) class I human leukocyte antigens for donor inhibitory killer cell immunoglobulin-like receptors (KIRs) following T-cell-replete haplo-SCT. We also addressed whether recipient expression of class I ligands for donor inhibitory KIRs could predict relapse occurrence in another cohort of 188 patients. A longitudinal analysis indicated that patients presenting class I for all donor inhibitory KIRs showed more capable functional NK effector cells when tested against class I negative K562 cells and primary leukemic cells within 3 months of transplantation. The lowest 7-year relapse incidence was observed when donor KIRs were ligated by recipient class I (n = 60) compared with donor host partnerships where donor KIR+ cells were ligated by donor, but not recipient class I (n = 86, p = 0.026) or KIRs that were ligated by neither donor nor recipient class I (n = 42, p = 0.043). This study suggests that haplo-SCT recipients presenting class I for donor inhibitory KIRs promote NK-cell licensing, leading to decreased relapse rates.

语种英语
WOS记录号WOS:000359674200024
项目编号81270644 ; 81230013 ; 2013CB733700 ; 20110001110039
资助机构National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Collaborative Innovation Center of Hematology, Peking University, China ; Ministry of Education of China ; Milstein Medical Asian American Partnership (MMAAP) Foundation Research Project Award in Hematology
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56301
专题北京大学第二临床医学院_血液科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
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GB/T 7714
Zhao, Xiang-Yu,Chang, Ying-Jun,Zhao, Xiao-Su,et al. Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2015,45(8):2396-2408.
APA Zhao, Xiang-Yu.,Chang, Ying-Jun.,Zhao, Xiao-Su.,Xu, Lan-Ping.,Zhang, Xiao-Hui.,...&Huang, Xiao-Jun.(2015).Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation.EUROPEAN JOURNAL OF IMMUNOLOGY,45(8),2396-2408.
MLA Zhao, Xiang-Yu,et al."Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation".EUROPEAN JOURNAL OF IMMUNOLOGY 45.8(2015):2396-2408.
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