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学科主题: 口腔医学
题名:
NF-kappa B activation in human dental pulp stem cells by TNF and LPS
作者: Chang, J; Zhang, C; Tani-Ishii, N; Shi, S; Wang, CY
关键词: NF-kappa B ; dental pulp stem cells ; tumor necrosis factor ; LPS ; inflammation
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2005-11-01
卷: 84, 期:11, 页:994-998
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE ; GENE-EXPRESSION ; INDUCED APOPTOSIS ; PHOSPHORYLATION ; INHIBITION ; INDUCTION ; PROFILES ; THERAPY ; DEATH
英文摘要:

Post-natal human dental pulp stem cells (DPSCs) represent a unique precursor population in the dental pulp, which has multipotential and can regenerate a dentin/pulp-like structure. Because the dental pulp is frequently infected by oral bacteria due to dental decay, in this study, we examined whether lipopolysaccharide (LPS) and tumor necrosis factor (TNF) activated the immunologic transcription factor nuclear factor kappa B (NF-kappa B) in DPSCs. We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylation and degradation Of I kappa B alpha, resulting in the nuclear translocation of NF-kappa B. Consistently, both TNF and LPS rapidly induced the expression of the NF-kappa B-dependent gene interteukin-8 (IL-8). However, unlike in monocytes, we found that LPS could not induce the phosphorylation of the NF-kappa B active subunit p65 in DPSCs. In summary, our studies suggest that DPSCs may be involved in immune responses during pulpal infection through activating NF-kappa B.

语种: 英语
WOS记录号: WOS:000232801100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56304
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Sch Dent, Ann Arbor, MI 48109 USA
2.Kanagawa Dent Coll, Div Operat Dent & Endodont, Dept Oral Med, Kanagawa, Japan
3.Peking Univ, Hlth Sci Ctr, Sch Stomatol, Beijing 100871, Peoples R China
4.Natl Inst Dent & Craniofacial Res, Sect Oral Biol, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA

Recommended Citation:
Chang, J,Zhang, C,Tani-Ishii, N,et al. NF-kappa B activation in human dental pulp stem cells by TNF and LPS[J]. JOURNAL OF DENTAL RESEARCH,2005,84(11):994-998.
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