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学科主题口腔医学
NF-kappa B activation in human dental pulp stem cells by TNF and LPS
Chang, J; Zhang, C; Tani-Ishii, N; Shi, S; Wang, CY
关键词Nf-kappa b Dental Pulp Stem Cells Tumor Necrosis Factor Lps Inflammation
刊名JOURNAL OF DENTAL RESEARCH
2005-11-01
84期:11页:994-998
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE ; GENE-EXPRESSION ; INDUCED APOPTOSIS ; PHOSPHORYLATION ; INHIBITION ; INDUCTION ; PROFILES ; THERAPY ; DEATH
英文摘要

Post-natal human dental pulp stem cells (DPSCs) represent a unique precursor population in the dental pulp, which has multipotential and can regenerate a dentin/pulp-like structure. Because the dental pulp is frequently infected by oral bacteria due to dental decay, in this study, we examined whether lipopolysaccharide (LPS) and tumor necrosis factor (TNF) activated the immunologic transcription factor nuclear factor kappa B (NF-kappa B) in DPSCs. We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylation and degradation Of I kappa B alpha, resulting in the nuclear translocation of NF-kappa B. Consistently, both TNF and LPS rapidly induced the expression of the NF-kappa B-dependent gene interteukin-8 (IL-8). However, unlike in monocytes, we found that LPS could not induce the phosphorylation of the NF-kappa B active subunit p65 in DPSCs. In summary, our studies suggest that DPSCs may be involved in immune responses during pulpal infection through activating NF-kappa B.

语种英语
WOS记录号WOS:000232801100005
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56304
专题北京大学口腔医学院
作者单位1.Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Sch Dent, Ann Arbor, MI 48109 USA
2.Kanagawa Dent Coll, Div Operat Dent & Endodont, Dept Oral Med, Kanagawa, Japan
3.Peking Univ, Hlth Sci Ctr, Sch Stomatol, Beijing 100871, Peoples R China
4.Natl Inst Dent & Craniofacial Res, Sect Oral Biol, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA
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GB/T 7714
Chang, J,Zhang, C,Tani-Ishii, N,et al. NF-kappa B activation in human dental pulp stem cells by TNF and LPS[J]. JOURNAL OF DENTAL RESEARCH,2005,84(11):994-998.
APA Chang, J,Zhang, C,Tani-Ishii, N,Shi, S,&Wang, CY.(2005).NF-kappa B activation in human dental pulp stem cells by TNF and LPS.JOURNAL OF DENTAL RESEARCH,84(11),994-998.
MLA Chang, J,et al."NF-kappa B activation in human dental pulp stem cells by TNF and LPS".JOURNAL OF DENTAL RESEARCH 84.11(2005):994-998.
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