IR@PKUHSC  > 北京大学第一临床医学院  > 消化科
学科主题临床医学
Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents
Wang, WH; Wong, WM; Dailidiene, D; Berg, DE; Gu, Q; Lai, KC; Lam, SK; Wong, BCY
刊名GUT
2003-04-01
52期:4页:490-495
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ESCHERICHIA-COLI ; CAMPYLOBACTER-PYLORI ; ANTIBIOTIC-RESISTANCE ; OUTER-MEMBRANE ; PSEUDOMONAS-CEPACIA ; OMPF PORIN ; SALICYLATE ; PH ; EXPRESSION
英文摘要

Background and aim: The role of Helicobacter pylori and aspirin in peptic ulcer formation and recurrence remains an important clinical topic. The interaction between aspirin and H pylori in vitro is also not clear. We investigated the effect of aspirin on the growth of H pylori and on the susceptibility of H pylori to antimicrobials.

Methods: Time killing studies of H pylori were performed with different concentrations of aspirin and salicylate. Growth of bacteria was assessed spectrophotometrically and by viable colony count. The effects of aspirin on the efficiency of colony formation and on metronidazole induced mutation to rifampicin resistance in H pylori were determined. Minimal inhibitory concentrations (MICs) of aspirin and metronidazole were tested by the standard agar dilution method. MICs of amoxycillin and clarithromycin were determined by the E test method.

Results: Aspirin and salicylate inhibited the growth of H pylori in a dose dependent manner and bactericidal activity was due to cell lysis. Aspirin 400 mug/ml caused a 2 logs decrease in colony forming units/ml at 48 hours, and suppressed the normal ability of metronidazole to induce new mutations to rifampicin. The IC90 of aspirin was 512 mug/ml. Increased susceptibility of amoxycillin, clarithromycin, and metronidazole to H pylori was observed at 1 mM (180 mug/ml) aspirin.

Conclusions: Aspirin inhibited the growth of H pylori, suppressed the mutagenic effect of metronidazole, and enhanced the susceptibility of H pylori to antimicrobial agents. This mechanism is important in future drug development for effective clearing and overcoming resistance.

语种英语
WOS记录号WOS:000181828100008
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56313
专题北京大学第一临床医学院_消化科
作者单位1.Peking Univ, First Hosp, Dept Gastroenterol, Beijing, Peoples R China
2.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
3.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
推荐引用方式
GB/T 7714
Wang, WH,Wong, WM,Dailidiene, D,et al. Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents[J]. GUT,2003,52(4):490-495.
APA Wang, WH.,Wong, WM.,Dailidiene, D.,Berg, DE.,Gu, Q.,...&Wong, BCY.(2003).Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents.GUT,52(4),490-495.
MLA Wang, WH,et al."Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents".GUT 52.4(2003):490-495.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, WH]的文章
[Wong, WM]的文章
[Dailidiene, D]的文章
百度学术
百度学术中相似的文章
[Wang, WH]的文章
[Wong, WM]的文章
[Dailidiene, D]的文章
必应学术
必应学术中相似的文章
[Wang, WH]的文章
[Wong, WM]的文章
[Dailidiene, D]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。