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HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy
Ollila, Hanna M.1; Ravel, Jean-Marie1; Han, Fang2; Faraco, Juliette1; Lin, Ling1; Zheng, Xiuwen3; Plazzi, Giuseppe4,5; Dauvilliers, Yves6; Pizza, Fabio4,5; Hong, Seung-Chul7; Jennum, Poul8; Knudsen, Stine9; Kornum, Birgitte R.8,10; Dong, Xiao Song2; Yan, Han2; Hong, Heeseung1; Coquillard, Cristin11; Mahlios, Joshua1; Jolanki, Otto1; Einen, Mali1; Lavault, Sophie12; Hoegl, Birgit13; Frauscher, Birgit13; Crowe, Catherine14; Partinen, Markku15,16; Huang, Yu Shu17; Bourgin, Patrice18; Vaarala, Outi19; Desautels, Alex20,21; Montplaisir, Jacques20,22; Mack, Steven J.23; Mindrinos, Michael24; Fernandez-Vina, Marcelo11; Mignot, Emmanuel1
刊名AMERICAN JOURNAL OF HUMAN GENETICS
2015-01-08
DOI10.1016/j.ajhg.2014.12.010
96期:1页:136-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]GENOME-WIDE ASSOCIATION ; DIABETES GENETICS CONSORTIUM ; MULTIPLE-SCLEROSIS ; ETHNIC-GROUPS ; HEPATITIS-B ; SUSCEPTIBILITY ; VACCINATION ; ALLELES ; ONSET ; POPULATION
英文摘要

Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly associated with human leukocyte antigen (HLA) class II HLA-DQA1*01:02-DQB1*06:02 (DQ0602) that very few non-DQ0602 cases have been reported. A known triggering factor for narcolepsy is pandemic 2009 influenza H1N1, suggesting autoimmunity triggered by upper-airway infections. Additional effects of other HLA-DQ alleles have been reported consistently across multiple ethnic groups. Using over 3,000 case and 10,000 control individuals of European and Chinese background, we examined the effects of other HLA loci. After careful matching of HLA-DR and HLA-DQ in case and control individuals, we found strong protective effects of HLA-DPA1*01:03-DPB1*04:02 (DP0402; odds ratio [OR] = 0.51 [0.38-0.67], p = 1.01 x 10(-6)) and HLA-DPA1*01:03-DPB1*04:01 (DP0401; OR = 0.61 [0.47-0.80], p = 2.07 x 10(-4)) and predisposing effects of HLA-DPB1*05:01 in Asians (OR = 1.76 [1.34-2.31], p = 4.71 x 10(-05)). Similar effects were found by conditional analysis controlling for HLA-DR and HLA-DQ with DP0402 (OR = 0.45 [0.38-0.55] p = 8.99 x 10(-17)) and DP0501 (OR = 1.38 [1.18-1.61], p = 7.11 x 10(-5)). HLA-class-II-independent associations with HLA-A*11:01 (OR = 1.32 [1.13-1.54], p = 4.92 x 10(-4)), HLA-B*35:03 (OR similar to 1.96 [1.41-2.70], p = 5.14 x 10(-5)), and HLA-B*51:01 (OR = 1.49 [1.25-1.78], p = 1.09 x 10(-5)) were also seen across ethnic groups in the HLA class I region. These effects might reflect modulation of autoimmunity or indirect effects of HLA class I and HLA-DP alleles on response to viral infections such as that of influenza.

语种英语
WOS记录号WOS:000347707800010
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56314
专题北京大学第二临床医学院_呼吸科
作者单位1.Stanford Univ, Ctr Sleep Sci, Palo Alto, CA 94304 USA
2.Peking Univ, Peoples Hosp, Dept Pulm Med, Beijing 100044, Peoples R China
3.Univ Washington, Dept Biostat, Seattle, WA 98195 USA
4.Univ Bologna, Dept Biomed & Neuromotor Sci, I-40123 Bologna, Italy
5.IRCCS Inst Neurol Sci, I-40139 Bologna, Italy
6.Ctr Hosp Reg Univ Montpellier, Gui de Chauliac Hosp, Dept Neurol, INSERM U1061,Reference Ctr Narcolepsy,Sleep Wake, F-34090 Montpellier, France
7.Catholic Univ Korea, St Vincents Hosp, Dept Psychiat, Suwon 442723, South Korea
8.Univ Copenhagen, Glostrup Hosp, Dept Clin Neurophysiol, Danish Ctr Sleep Med, DK-2600 Glostrup, Denmark
9.Oslo Univ Hosp, Norwegian Resource Ctr ADHD TS & Narcolepsy, N-0450 Ulleval, Norway
10.Glostrup Cty Hosp, Dept Diagnost, Mol Sleep Lab, DK-2600 Glostrup, Denmark
11.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94304 USA
12.Ctr Natl Reference Narcolepsie & Hypersomnie, F-75019 Paris, France
13.Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria
14.Mater Private Hosp, Dublin 7, Ireland
15.Helsinki Sleep Clin, Vitalmed Res Ctr, Helsinki 00420, Finland
16.Univ Helsinki, Dept Clin Neurosci, SF-00100 Helsinki, Finland
17.Chang Gung Mem Hosp & Univ, Taipei 10591, Taiwan
18.Strasbourg Univ, Strasbourg Univ Hosp, Dept Sleep Med, F-67084 Strasbourg, France
19.Univ Helsinki, Inst Clin Med, SF-00100 Helsinki, Finland
20.Hop Sacre Coeur, Ctr Adv Res Sleep Med, Montreal, PQ H3T 1J4, Canada
21.Univ Montreal, Dept Neurosci, Montreal, PQ H3T 1J4, Canada
22.Univ Montreal, Dept Psychiat, Montreal, PQ H3T 1J4, Canada
23.Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA
24.Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA
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GB/T 7714
Ollila, Hanna M.,Ravel, Jean-Marie,Han, Fang,et al. HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2015,96(1):136-146.
APA Ollila, Hanna M..,Ravel, Jean-Marie.,Han, Fang.,Faraco, Juliette.,Lin, Ling.,...&Mignot, Emmanuel.(2015).HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy.AMERICAN JOURNAL OF HUMAN GENETICS,96(1),136-146.
MLA Ollila, Hanna M.,et al."HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy".AMERICAN JOURNAL OF HUMAN GENETICS 96.1(2015):136-146.
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