北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization
作者: Liao, Xue-Yan1,2; Zhou, Zhen-Zuo3; Wei, Fu-Bang3; Qin, Han-Ning3; Ling, Yuan3; Li, Rong-Cheng4; Li, Yan-Ping4; Nong, Yi4; Sun, Kui-Xia1,2; Li, Jie1,2; Zhuang, Hui1,2
关键词: hepatitis B ; seroprevalence ; hepatitis B vaccine ; immune response ; college students
刊名: HUMAN VACCINES & IMMUNOTHERAPEUTICS
发表日期: 2014
DOI: 10.4161/hv.26311
卷: 10, 期:1, 页:224-231
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]: ARCHITECT(R) ANTI-HBC ; HEALTH-CARE WORKERS ; CORE ANTIGEN ; TAIWAN ; VACCINES ; IMMUNOGENICITY ; POPULATIONS ; ANTIBODIES ; BOOSTERS ; INFANTS
英文摘要:

The prevalence of hepatitis B surface antigen (HBsAg) in a population aged 15 y or older was high in China, but an immunization strategy for this population was unavailable. We investigated the seroprevalence of hepatitis B and immune response to HBV vaccine in Chinese college students (n = 2040 participants), 11.1%, 80.8%, and 8.1% had confirmed, unknown and no HBV vaccination history, respectively. The seropositive rates for HBsAg, anti-HBs sole and antiHBs plus anti-HBc were 12.6%, 25.7%, and 30.1%, respectively. The HBsAg seropositive rate was significantly lower in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (5.3%, 13.6%, and 12.6%, respectively, P = 0.0019). The anti-HBs alone seropositive rate was significantly higher in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (37.6%, 25.3%, and 13.8%, respectively, P < 0.0001). Participants negative for HBsAg, anti-HBs, and anti-HBc at baseline (n = 600) were given three doses of recombinant HBV vaccine (GlaxoSmithKline) at month 0, 1, and 6. Robust immune response was elicited after two and three doses (seroprotective rate: 91.9% and 99.0%, respectively, and geometric mean concentration [ GMC]: 95.8 and 742.6 IU/L, respectively). Fourteen months after the third dose, the anti-HBs seroprotective rate of the group remained more than 97%. The seroprotective rates and GMCs did not differ significantly by vaccination history. This study suggested that three doses of 20 g HBV vaccine were needed for college students negative for HBsAg, anti-HBs, and antiHBc to ensure high seroprotective rates and concentrations.

语种: 英语
所属项目编号: 2012ZX10002001
项目资助者: Major Science and Technology Special Project of China twelfth Five-year Plan
WOS记录号: WOS:000336258800032
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56318
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization.pdf(1044KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Guangxi Univ Sci & Technol, Liuzhou, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Infect Dis Ctr, Beijing 100871, Peoples R China
4.Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China

Recommended Citation:
Liao, Xue-Yan,Zhou, Zhen-Zuo,Wei, Fu-Bang,et al. Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2014,10(1):224-231.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liao, Xue-Yan]'s Articles
[Zhou, Zhen-Zuo]'s Articles
[Wei, Fu-Bang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liao, Xue-Yan]‘s Articles
[Zhou, Zhen-Zuo]‘s Articles
[Wei, Fu-Bang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace