IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization
Liao, Xue-Yan1,2; Zhou, Zhen-Zuo3; Wei, Fu-Bang3; Qin, Han-Ning3; Ling, Yuan3; Li, Rong-Cheng4; Li, Yan-Ping4; Nong, Yi4; Sun, Kui-Xia1,2; Li, Jie1,2; Zhuang, Hui1,2
关键词hepatitis B seroprevalence hepatitis B vaccine immune response college students
刊名HUMAN VACCINES & IMMUNOTHERAPEUTICS
2014
DOI10.4161/hv.26311
10期:1页:224-231
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology
资助者Major Science and Technology Special Project of China twelfth Five-year Plan ; Major Science and Technology Special Project of China twelfth Five-year Plan
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology
关键词[WOS]ARCHITECT(R) ANTI-HBC ; HEALTH-CARE WORKERS ; CORE ANTIGEN ; TAIWAN ; VACCINES ; IMMUNOGENICITY ; POPULATIONS ; ANTIBODIES ; BOOSTERS ; INFANTS
英文摘要

The prevalence of hepatitis B surface antigen (HBsAg) in a population aged 15 y or older was high in China, but an immunization strategy for this population was unavailable. We investigated the seroprevalence of hepatitis B and immune response to HBV vaccine in Chinese college students (n = 2040 participants), 11.1%, 80.8%, and 8.1% had confirmed, unknown and no HBV vaccination history, respectively. The seropositive rates for HBsAg, anti-HBs sole and antiHBs plus anti-HBc were 12.6%, 25.7%, and 30.1%, respectively. The HBsAg seropositive rate was significantly lower in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (5.3%, 13.6%, and 12.6%, respectively, P = 0.0019). The anti-HBs alone seropositive rate was significantly higher in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (37.6%, 25.3%, and 13.8%, respectively, P < 0.0001). Participants negative for HBsAg, anti-HBs, and anti-HBc at baseline (n = 600) were given three doses of recombinant HBV vaccine (GlaxoSmithKline) at month 0, 1, and 6. Robust immune response was elicited after two and three doses (seroprotective rate: 91.9% and 99.0%, respectively, and geometric mean concentration [ GMC]: 95.8 and 742.6 IU/L, respectively). Fourteen months after the third dose, the anti-HBs seroprotective rate of the group remained more than 97%. The seroprotective rates and GMCs did not differ significantly by vaccination history. This study suggested that three doses of 20 g HBV vaccine were needed for college students negative for HBsAg, anti-HBs, and antiHBc to ensure high seroprotective rates and concentrations.

语种英语
所属项目编号2012ZX10002001
资助者Major Science and Technology Special Project of China twelfth Five-year Plan ; Major Science and Technology Special Project of China twelfth Five-year Plan
WOS记录号WOS:000336258800032
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56318
Collection北京大学基础医学院_病原生物学系
作者单位1.Guangxi Univ Sci & Technol, Liuzhou, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Infect Dis Ctr, Beijing 100871, Peoples R China
4.Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China
Recommended Citation
GB/T 7714
Liao, Xue-Yan,Zhou, Zhen-Zuo,Wei, Fu-Bang,et al. Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS,2014,10(1):224-231.
APA Liao, Xue-Yan.,Zhou, Zhen-Zuo.,Wei, Fu-Bang.,Qin, Han-Ning.,Ling, Yuan.,...&Zhuang, Hui.(2014).Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization.HUMAN VACCINES & IMMUNOTHERAPEUTICS,10(1),224-231.
MLA Liao, Xue-Yan,et al."Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization".HUMAN VACCINES & IMMUNOTHERAPEUTICS 10.1(2014):224-231.
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