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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Predictive value of postprocedural leukocyte count on myocardial perfusion, left ventricular function and clinical outcomes in ST-elevated myocardial infarction after percutaneous coronary intervention
作者: He Rong1,2,3; Li Hai-yan1,2,3; Guo Li-jun1,2,3; Zhang Fu-chun1,2,3; Niu Jie1,2,3; Zhang Yong-zhen1,2,3; Wang Gui-song1,2,3; Yang Zhen-hua1,2,3; Gao Wei1,2,3
关键词: angioplasty, transluminal, percutaneous coronary ; leukocyte ; myocardial infarction ; left ventricular dysfunction ; prognosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-03-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.06.012
卷: 125, 期:6, 页:1023-1029
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BLOOD-CELL COUNT ; LONG-TERM MORTALITY ; PRIMARY ANGIOPLASTY ; SEGMENT ELEVATION ; HEART-DISEASE ; SUCCESSFUL REPERFUSION ; INJURY ; INFLAMMATION ; ASSOCIATION ; PREVENTION
英文摘要:

Background Baseline white blood cell (WBC) count was correlated with ischemic events occurrence in patients with ST-elevated myocardial infarction (STEMI). However, circulating WBC count is altered after percutaneous coronary intervention (PCI). The aim of this study was to assess the relationship between postprocedural WBC count and clinical outcomes in STEMI patients who underwent PCI.

Methods A total of 242 consecutive acute STEMI patients who underwent successful primary PCI were enrolled and followed up for two years. WBC counts were measured within 12 hours after PCI. ST-segment resolution (ST-R) and myocardial blush grades (MBG) were evaluated immediately after PCI. Left ventricular ejection fraction (LVEF) was obtained at baseline and 12-18 months after PCI.

Results Postprocedural WBC count was an independent inverse predictor of ST-R (OR 0.80, P<0.0001) and MBG 3 (OR 0.82, P <0.0001). It was negatively correlated with LVEF (baseline r=-0.22, P=0.001; 12-18 months r=-0.29, P <0.0001). The best cutoff value of WBC for predicting death was determined to be 13.0x10(9)/L. The patients with a postprocedural WBC count above 13.0x109/L showed a significantly lower cumulative survival rate (30 days, 82.4% vs. 99.0%, P <0.0001 and 2 years 75.0% vs. 96.4%, P <0.0001). Multivariate Cox regression analysis showed that a postprocedural WBC count was a strong independent predictor of 30-day mortality (HR 8.48, P=0.019) and 2-year mortality (HR 4.93, P=0.009).

Conclusions Increased postprocedural WBC count is correlated with myocardial malperfusion and left ventricular dysfunction, and is an independent predictor of poor clinical outcomes in STEMI patients who underwent POI. Chin Med J 2012;125(6):1023-1029

语种: 英语
WOS记录号: WOS:000302882500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56322
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Cardiol, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
He Rong,Li Hai-yan,Guo Li-jun,et al. Predictive value of postprocedural leukocyte count on myocardial perfusion, left ventricular function and clinical outcomes in ST-elevated myocardial infarction after percutaneous coronary intervention[J]. CHINESE MEDICAL JOURNAL,2012,125(6):1023-1029.
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