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学科主题临床医学
Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population
Wang, Ylijue1; Zhang, Lian1; Moslehi, Roxana2; Ma, Junling1; Pan, Kaifeng1; Zhou, Tong1; Liu, Weidong3; Brown, Linda Morris; Hu, Yuangreng; Pee, David4; Gail, Mitchell H.; You, Weicheng1
刊名JOURNAL OF NUTRITION
2009
DOI10.3945/jn.108.091389
139期:1页:106-112
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]PRECANCEROUS GASTRIC-LESIONS ; PLASMA GLUTATHIONE ; FOLIC-ACID ; RANDOMIZED FACTORIAL ; ANTIBIOTIC-TREATMENT ; ATROPHIC GASTRITIS ; CONTROLLED-TRIAL ; STOMACH-CANCER ; RISK-FACTOR ; DEFICIENCY
英文摘要

The effects of a 7.3-y supplementation with garlic and micronutrients and of anti-Helicobacter pylori treatment with amoxicillin (1 g twice daily) and omeprazole (20 mg twice daily) on serum folate, vitamin B-12, homocysteine, and glutathione concentrations were assessed in a rural Chinese population. A randomized, double-blind, placebo-controlled, factorial trial was conducted to compare the ability of 3 treatments to retard the development of precancerous gastric lesions in 3411 subjects. The treatments were: 7) anti-H. pylori treatment with amoxicillin and omeprazole; 2) 7.3-y supplementation with aged garlic and steam-distilled garlic oil; and 3) 7.3-y supplementation with vitamin C, vitamin E, and selenium. All 3 treatments were given in a 23 factorial design to subjects seropositive for H. pylori infection; only the garlic supplement and vitamin and selenium supplement were given in a 22 factorial design to the other subjects. Thirty-four subjects were randomly selected from each of the 12 treatment strata. Sera were analyzed after 7.3 y to measure effects on folate, vitamin B-12, homocysteine, and glutathione concentrations. Regression analyses adjusted for age, gender, and smoking indicated an increase of 10.2% (95%CI: 2.9-18.1 %) in serum folate after garlic supplementation and an increase of 13.4% (95%CI: 5.3-22.2%) in serum glutathione after vitamin and selenium supplementation. The vitamin and selenium supplement did not affect other analytes and the amoxicillin and omeprazole therapy did not affect any of the variables tested. In this rural Chinese population, 7.3 y of garlic supplementation increased the serum folate concentration and the vitamin and selenium supplement increased that of glutathione, but neither affected serum concentrations of vitamin B-12 or homocysteine. J. Nutr. 139: 106-112, 2009.

语种英语
WOS记录号WOS:000261777100019
项目编号N01-CP-71103
资助机构National Cancer Institute ; Intramural Research Program of the National Cancer Institute Division of Cancer Epidemiology and Genetics ; Peking University School of Oncology ; Key Laboratory of Carcinogenesis and Translation Research (Ministry of Education)
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56323
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_党院办公室
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Dept Epidemiol,Minist Educ, Beijing 100036, Peoples R China
2.Linque Publ Hlth Bur, Shandong 262600, Peoples R China
3.Informat Management Serv Inc, Rockville, MD 20852 USA
4.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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GB/T 7714
Wang, Ylijue,Zhang, Lian,Moslehi, Roxana,et al. Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population[J]. JOURNAL OF NUTRITION,2009,139(1):106-112.
APA Wang, Ylijue.,Zhang, Lian.,Moslehi, Roxana.,Ma, Junling.,Pan, Kaifeng.,...&You, Weicheng.(2009).Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population.JOURNAL OF NUTRITION,139(1),106-112.
MLA Wang, Ylijue,et al."Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population".JOURNAL OF NUTRITION 139.1(2009):106-112.
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