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学科主题: 临床医学
题名:
Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population
作者: Wang, Ylijue1; Zhang, Lian1; Moslehi, Roxana2; Ma, Junling1; Pan, Kaifeng1; Zhou, Tong1; Liu, Weidong3; Brown, Linda Morris; Hu, Yuangreng; Pee, David4; Gail, Mitchell H.; You, Weicheng1
刊名: JOURNAL OF NUTRITION
发表日期: 2009
DOI: 10.3945/jn.108.091389
卷: 139, 期:1, 页:106-112
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: PRECANCEROUS GASTRIC-LESIONS ; PLASMA GLUTATHIONE ; FOLIC-ACID ; RANDOMIZED FACTORIAL ; ANTIBIOTIC-TREATMENT ; ATROPHIC GASTRITIS ; CONTROLLED-TRIAL ; STOMACH-CANCER ; RISK-FACTOR ; DEFICIENCY
英文摘要:

The effects of a 7.3-y supplementation with garlic and micronutrients and of anti-Helicobacter pylori treatment with amoxicillin (1 g twice daily) and omeprazole (20 mg twice daily) on serum folate, vitamin B-12, homocysteine, and glutathione concentrations were assessed in a rural Chinese population. A randomized, double-blind, placebo-controlled, factorial trial was conducted to compare the ability of 3 treatments to retard the development of precancerous gastric lesions in 3411 subjects. The treatments were: 7) anti-H. pylori treatment with amoxicillin and omeprazole; 2) 7.3-y supplementation with aged garlic and steam-distilled garlic oil; and 3) 7.3-y supplementation with vitamin C, vitamin E, and selenium. All 3 treatments were given in a 23 factorial design to subjects seropositive for H. pylori infection; only the garlic supplement and vitamin and selenium supplement were given in a 22 factorial design to the other subjects. Thirty-four subjects were randomly selected from each of the 12 treatment strata. Sera were analyzed after 7.3 y to measure effects on folate, vitamin B-12, homocysteine, and glutathione concentrations. Regression analyses adjusted for age, gender, and smoking indicated an increase of 10.2% (95%CI: 2.9-18.1 %) in serum folate after garlic supplementation and an increase of 13.4% (95%CI: 5.3-22.2%) in serum glutathione after vitamin and selenium supplementation. The vitamin and selenium supplement did not affect other analytes and the amoxicillin and omeprazole therapy did not affect any of the variables tested. In this rural Chinese population, 7.3 y of garlic supplementation increased the serum folate concentration and the vitamin and selenium supplement increased that of glutathione, but neither affected serum concentrations of vitamin B-12 or homocysteine. J. Nutr. 139: 106-112, 2009.

语种: 英语
所属项目编号: N01-CP-71103
项目资助者: National Cancer Institute ; Intramural Research Program of the National Cancer Institute Division of Cancer Epidemiology and Genetics ; Peking University School of Oncology ; Key Laboratory of Carcinogenesis and Translation Research (Ministry of Education)
WOS记录号: WOS:000261777100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56323
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Dept Epidemiol,Minist Educ, Beijing 100036, Peoples R China
2.Linque Publ Hlth Bur, Shandong 262600, Peoples R China
3.Informat Management Serv Inc, Rockville, MD 20852 USA
4.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

Recommended Citation:
Wang, Ylijue,Zhang, Lian,Moslehi, Roxana,et al. Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population[J]. JOURNAL OF NUTRITION,2009,139(1):106-112.
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