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学科主题临床医学
Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
Xue, Yan1; Zhou, Li-Ya1; Lin, San-Ren1; Hou, Xiao-Hua2; Li, Zhao-Shen3; Chen, Min-Hu4; Yan, Xiu-E1; Meng, Ling-Mei1; Zhang, Jing1; Lu, Jing-Jing1
关键词Gastroesophageal Reflux Disease Helicobacter Pylori Reflux Esophagitis Therapy
刊名CHINESE MEDICAL JOURNAL
2015-04-20
DOI10.4103/0366-6999.155049
128期:8页:995-999
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Science and Technology Pillar Program of 11th Five-year Plan in China ; National Science and Technology Pillar Program of 11th Five-year Plan in China
研究领域[WOS]General & Internal Medicine
关键词[WOS]DISEASE ; INFECTION ; CONSENSUS ; GUIDELINES ; MANAGEMENT ; SEVERITY
英文摘要

Background: Helicobacter pylori (H. pylori) frequently colonizes the stomach. Gastroesophageal reflux disease (GERD) is a common and costly disease. But the relationship of Helicobacter pylori and GERD is still unclear. This study aimed to explore the effect of Helicobacter pylori and its eradication on reflux esophagitis therapy.

Methods: Patients diagnosed with reflux esophagitis by endoscopy were enrolled; based on rapid urease test and Warth-Starry stain, they were divided into Helicobacter pylori positive and negative groups. Helicobacter pylori positive patients were randomly given Helicobacter pylori eradication treatment for 10 days, then esomeprazole 20 mg bid for 46 days. The other patients received esomeprazole 20 mg bid therapy for 8 weeks. After treatment, three patient groups were obtained: Helicobacter pylori positive eradicated, Helicobacter pylori positive uneradicated, and Helicobacter pylori negative. Before and after therapy, reflux symptoms were scored and compared. Healing rates were compared among groups. The chi(2) test and t-test were used, respectively, for enumeration and measurement data.

Results: There were 176 Helicobacter pylori positive (with 92 eradication cases) and 180 negative cases. Healing rates in the Helicobacter pylori positive eradicated and Helicobacter pylori positive uneradicated groups reached 80.4% and 79.8% (P = 0.911), with reflux symptom scores of 0.22 and 0.14 (P = 0.588). Healing rates of esophagitis in the Helicobacter pylori positive uneradicated and Helicobacter pylori negative groups were, respectively, 79.8% and 82.2% (P = 0.848); reflux symptom scores were 0.14 and 0.21 (P = 0.546).

Conclusions: Based on esomeprazole therapy, Helicobacter pylori infection and eradication have no significant effect on reflux esophagitis therapy.

语种英语
所属项目编号2007BAI04B02
资助者National Science and Technology Pillar Program of 11th Five-year Plan in China ; National Science and Technology Pillar Program of 11th Five-year Plan in China
WOS记录号WOS:000353563300001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56332
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Huazhong Univ Sci & Technol, Wuhan Union Hosp, Tongji Med Coll, Dept Gastroenterol, Huhan 430022, Hubei, Peoples R China
3.Shanghai Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510080, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Xue, Yan,Zhou, Li-Ya,Lin, San-Ren,et al. Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study[J]. CHINESE MEDICAL JOURNAL,2015,128(8):995-999.
APA Xue, Yan.,Zhou, Li-Ya.,Lin, San-Ren.,Hou, Xiao-Hua.,Li, Zhao-Shen.,...&Lu, Jing-Jing.(2015).Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study.CHINESE MEDICAL JOURNAL,128(8),995-999.
MLA Xue, Yan,et al."Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study".CHINESE MEDICAL JOURNAL 128.8(2015):995-999.
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