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Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus
Ding, Ye; Dai, Xiaoqian; Jiang, Yanfei; Zhang, Zhaofeng; Li, Yong
关键词Calcium Grape Seed Proanthocyanidins Pathology Peripheral Nervous System Diseases Type 2 Diabetes Mellitus
刊名PHYTOTHERAPY RESEARCH
2014-07-01
DOI10.1002/ptr.5104
28期:7页:1082-1087
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; TACTILE ALLODYNIA ; DYSFUNCTION ; EXTRACT ; MICE ; DIET ; INHIBITION ; ACTIVATION ; NEURONS
英文摘要

Grape seed proanthocyanidins (GSPs) possess a broad spectrum of pharmacological and therapeutic properties. The aim of this study was to examine the effect of GSPs on functional and morphological abnormalities in the peripheral nerves of rats with type 2 diabetes mellitus. Diabetic rats were induced by two injections of 25mg streptozotocin/kg body weight and 8weeks of a high-carbohydrate/high-fat diet. GSPs were then administrated to the rats for 16weeks. Thermal and mechanical sensitivity thresholds and nerve conductive velocity were measured to evaluate peripheral nerve function. Light microscopy was used with special stains to observe the morphological changes in the central and peripheral nervous systems. Calcium (Ca2+) homeostasis and ATPase activities in the sciatic nerves were also determined. In diabetic rats receiving GSP treatment (especially at the 500 mg/kg dose), the abnormal peripheral nerve function and impaired nervous tissues (L4 to L5 spinal cord segments, L5 dorsal root ganglion, and sciatic nerves) were improved to a significant extent. Moreover, 500 mg/kg GSP treatment significantly reduced the concentration of free Ca2+ and elevated Ca2+-ATPase activity in sciatic nerves. These results suggest that GSPs may prevent early functional and morphological abnormalities in the peripheral nerves of rats with type 2 diabetes mellitus. Copyright (C) 2013 John Wiley & Sons, Ltd.

语种英语
所属项目编号81072293
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000339518800017
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56338
Collection北京大学公共卫生学院
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ding, Ye,Dai, Xiaoqian,Jiang, Yanfei,et al. Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus[J]. PHYTOTHERAPY RESEARCH,2014,28(7):1082-1087.
APA Ding, Ye,Dai, Xiaoqian,Jiang, Yanfei,Zhang, Zhaofeng,&Li, Yong.(2014).Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus.PHYTOTHERAPY RESEARCH,28(7),1082-1087.
MLA Ding, Ye,et al."Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus".PHYTOTHERAPY RESEARCH 28.7(2014):1082-1087.
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