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学科主题: 公共卫生
题名:
Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus
作者: Ding, Ye; Dai, Xiaoqian; Jiang, Yanfei; Zhang, Zhaofeng; Li, Yong
关键词: calcium ; grape seed proanthocyanidins ; pathology ; peripheral nervous system diseases ; type 2 diabetes mellitus
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2014-07-01
DOI: 10.1002/ptr.5104
卷: 28, 期:7, 页:1082-1087
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; TACTILE ALLODYNIA ; DYSFUNCTION ; EXTRACT ; MICE ; DIET ; INHIBITION ; ACTIVATION ; NEURONS
英文摘要:

Grape seed proanthocyanidins (GSPs) possess a broad spectrum of pharmacological and therapeutic properties. The aim of this study was to examine the effect of GSPs on functional and morphological abnormalities in the peripheral nerves of rats with type 2 diabetes mellitus. Diabetic rats were induced by two injections of 25mg streptozotocin/kg body weight and 8weeks of a high-carbohydrate/high-fat diet. GSPs were then administrated to the rats for 16weeks. Thermal and mechanical sensitivity thresholds and nerve conductive velocity were measured to evaluate peripheral nerve function. Light microscopy was used with special stains to observe the morphological changes in the central and peripheral nervous systems. Calcium (Ca2+) homeostasis and ATPase activities in the sciatic nerves were also determined. In diabetic rats receiving GSP treatment (especially at the 500 mg/kg dose), the abnormal peripheral nerve function and impaired nervous tissues (L4 to L5 spinal cord segments, L5 dorsal root ganglion, and sciatic nerves) were improved to a significant extent. Moreover, 500 mg/kg GSP treatment significantly reduced the concentration of free Ca2+ and elevated Ca2+-ATPase activity in sciatic nerves. These results suggest that GSPs may prevent early functional and morphological abnormalities in the peripheral nerves of rats with type 2 diabetes mellitus. Copyright (C) 2013 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 81072293
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000339518800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56338
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Ding, Ye,Dai, Xiaoqian,Jiang, Yanfei,et al. Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus[J]. PHYTOTHERAPY RESEARCH,2014,28(7):1082-1087.
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