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学科主题: 基础医学
题名:
mTOR and the differentiation of mesenchymal stem cells
作者: Xiang, Xinxin1; Zhao, Jing1; Xu, Geyang1; Li, Yin1; Zhang, Weizhen1,2
关键词: mTOR ; differentiation ; mesenchymal stem cells ; adipogenesis ; myogenesis ; osteogenesis
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2011-07-01
DOI: 10.1093/abbs/gmr041
卷: 43, 期:7, 页:501-510
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: P70 S6 KINASE ; RAPAMYCIN-SENSITIVE PATHWAY ; ACTIVATED RECEPTOR-GAMMA ; PIK-RELATED KINASES ; MAMMALIAN TARGET ; ADIPOCYTE DIFFERENTIATION ; OSTEOGENIC DIFFERENTIATION ; SKELETAL MYOGENESIS ; PROTEIN-KINASE ; OSTEOBLAST DIFFERENTIATION
英文摘要:

The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine-threonine protein kinase, belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family, which contains a lipid kinase-like domain within their C-terminal region. Recent studies have revealed that mTOR as a critical intracellular molecule can sense the extracellular energy status and regulate the cell growth and proliferation in a variety of cells and tissues. This review summarizes our current understanding about the effects of mTOR on cell differentiation and tissue development, with an emphasis on the lineage determination of mesenchymal stem cells. mTOR can promote adipogenesis in white adipocytes, brown adipocytes, and muscle satellite cells, while rapamycin inhibits the adipogenic function of mTOR. mTOR signaling may function to affect osteoblast proliferation and differentiation, however, rapamycin has been reported to either inhibit or promote osteogenesis. Although the precise mechanism remains unclear, mTOR is indispensable for myogenesis. Depending on the cell type, rapamycin has been reported to inhibit, promote, or have no effect on myogenesis.

语种: 英语
所属项目编号: 81030012 ; 30890043 ; 30971434 ; 30871194 ; 30821001 ; 30700376 ; 30971085 ; 2010CB912504 ; 7112080
项目资助者: National Natural Science Foundation of China ; Major National Basic Research Program of China ; Program for New Century Excellent Talents in University ; Beijing Natural Science Foundation
WOS记录号: WOS:000292337100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56340
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ,Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

Recommended Citation:
Xiang, Xinxin,Zhao, Jing,Xu, Geyang,et al. mTOR and the differentiation of mesenchymal stem cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(7):501-510.
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