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学科主题基础医学
mTOR and the differentiation of mesenchymal stem cells
Xiang, Xinxin1; Zhao, Jing1; Xu, Geyang1; Li, Yin1; Zhang, Weizhen1,2
关键词Mtor Differentiation Mesenchymal Stem Cells Adipogenesis Myogenesis Osteogenesis
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2011-07-01
DOI10.1093/abbs/gmr041
43期:7页:501-510
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]P70 S6 KINASE ; RAPAMYCIN-SENSITIVE PATHWAY ; ACTIVATED RECEPTOR-GAMMA ; PIK-RELATED KINASES ; MAMMALIAN TARGET ; ADIPOCYTE DIFFERENTIATION ; OSTEOGENIC DIFFERENTIATION ; SKELETAL MYOGENESIS ; PROTEIN-KINASE ; OSTEOBLAST DIFFERENTIATION
英文摘要

The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine-threonine protein kinase, belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family, which contains a lipid kinase-like domain within their C-terminal region. Recent studies have revealed that mTOR as a critical intracellular molecule can sense the extracellular energy status and regulate the cell growth and proliferation in a variety of cells and tissues. This review summarizes our current understanding about the effects of mTOR on cell differentiation and tissue development, with an emphasis on the lineage determination of mesenchymal stem cells. mTOR can promote adipogenesis in white adipocytes, brown adipocytes, and muscle satellite cells, while rapamycin inhibits the adipogenic function of mTOR. mTOR signaling may function to affect osteoblast proliferation and differentiation, however, rapamycin has been reported to either inhibit or promote osteogenesis. Although the precise mechanism remains unclear, mTOR is indispensable for myogenesis. Depending on the cell type, rapamycin has been reported to inhibit, promote, or have no effect on myogenesis.

语种英语
WOS记录号WOS:000292337100001
项目编号81030012 ; 30890043 ; 30971434 ; 30871194 ; 30821001 ; 30700376 ; 30971085 ; 2010CB912504 ; 7112080
资助机构National Natural Science Foundation of China ; Major National Basic Research Program of China ; Program for New Century Excellent Talents in University ; Beijing Natural Science Foundation
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56340
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ,Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA
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Xiang, Xinxin,Zhao, Jing,Xu, Geyang,et al. mTOR and the differentiation of mesenchymal stem cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(7):501-510.
APA Xiang, Xinxin,Zhao, Jing,Xu, Geyang,Li, Yin,&Zhang, Weizhen.(2011).mTOR and the differentiation of mesenchymal stem cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,43(7),501-510.
MLA Xiang, Xinxin,et al."mTOR and the differentiation of mesenchymal stem cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 43.7(2011):501-510.
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