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学科主题: 基础医学
题名:
Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants
作者: Peng, YH; Nishizawa, T; Takahashi, M; Ishikawa, T; Yoshikawa, A; Okamoto, H
刊名: ARCHIVES OF VIROLOGY
发表日期: 2002
卷: 147, 期:1, 页:21-41
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: ENTIRE NUCLEOTIDE-SEQUENCES ; CHICKEN ANEMIA VIRUS ; POSTTRANSFUSION HEPATITIS ; DIFFERENT GENOTYPES ; UNKNOWN ETIOLOGY ; MESSENGER-RNA ; DNA GENOME ; MINI VIRUS ; INFECTION ; HETEROGENEITY
英文摘要:

TT virus (TTV) DNA in serum samples obtained from 24 TTV-infected infants was amplified by polymerase chain reaction (PCR) with inverse primers derived from the untranslated region. The amplified PCR products were molecularly cloned; six clones each were analyzed. Seventy-six (53%) of the 144 TTV clones were classified into group 4 (YONBAN isolates), and 22 (15%) into a novel genetic group (group 5). The TTV clones in group 4 were classified into 9 types, and those in group 5 into 4 types. The entire nucleotide sequence of one representative clone each from the 13 types were determined; they comprised 3570-3770 nucleotides, and had poor homology to TTVs of groups 1-3 (TA278, PMV and SANBAN isolates). A phylogenetic tree based on the entire nucleotide sequence of open reading frame 1 confirmed the presence of five distinct clusters separated by a bootstrap value of 100%. Analysis of 13 TTV variants demonstrated preservation of the genomic organization and transcription profile in all TTV groups. TTV group 4 was detected in 54% or 72% of 7-to-12-month-old infants in Japan and China, respectively, which is comparable with that among adults in the respective country, indicating early and frequent acquisition of this TTV group in infancy.

语种: 英语
WOS记录号: WOS:000173539600003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56343
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Jichi Med Sch, Div Immunol, Minami Kawachi, Tochigi 3290498, Japan
2.Jichi Med Sch, Div Mol Virol, Minami Kawachi, Tochigi 3290498, Japan
3.Peking Univ, Sch Med, Dept Microbiol, Beijing 100871, Peoples R China
4.Nasuminami Hosp, Dept Pediat, Nasuminami, Tochigi, Japan
5.Japanese Red Cross Saitama Blood Ctr, Saitama, Japan

Recommended Citation:
Peng, YH,Nishizawa, T,Takahashi, M,et al. Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants[J]. ARCHIVES OF VIROLOGY,2002,147(1):21-41.
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