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学科主题: 基础医学
题名:
Coding of peripheral electrical stimulation frequency in thalamocortical pathways
作者: Yang, H; Chang, JY; Woodward, DJ; Baccala, LA; Han, JS; Luo, F
关键词: frequency perception ; frequency-specific response ; anterior cingulate cortex ; primary somatosensory cortex ; thalamus ; partial directed coherence ; transcutaneous electric nerve stimulation ; analgesia
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2005-11-01
DOI: 10.1016/j.expneurol.2005.07.019
卷: 196, 期:1, 页:138-152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PARTIAL DIRECTED COHERENCE ; COMPUTER-INTERFACE BCI ; MANY-NEURON ENSEMBLES ; SOMATOSENSORY SYSTEM ; SINGLE NEURON ; AWAKE RATS ; ELECTROACUPUNCTURE ; RESPONSES ; MODULATION ; ACUPUNCTURE
英文摘要:

Frequency information of the environment is an important feature for sensory perception. It has been demonstrated that cortical and thalamic neurons exhibited frequency-specific responses to peripheral stimulation. In the present study, we investigated the effects of 1-100 Hz peripheral electrical stimulations on various thalamic and cortical areas in awake rats. We used chronically implanted microelectrode arrays to record neural activities from the anterior cingulate cortex, primary somatosensory cortex, and medial dorsal and ventral posterior thalamus. The results revealed that cortical and thalamic neurons exhibited frequency-specific responses at both single-neuron and ensemble levels. Clusters of neurons responded to different frequency ranges with changes of both the peak firing rates and the phases of the peak responses in a stimulation cycle. Partial directed coherence analysis showed that information flowing between these recorded areas is also enhanced or inhibited in some frequency-specific pattern during stimulation. These evidences suggest that central nervous system may code environmental frequency information mainly with the activation of selected neural circuits according to their own intrinsic electrical properties. These properties, in turn, may facilitate or inhibit their responses when stimulation with specific frequency information arrives. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000232753000016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56344
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Wake Forest Univ, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
4.Univ Sao Paulo, Escola Politecn, BR-05508 Sao Paulo, Brazil

Recommended Citation:
Yang, H,Chang, JY,Woodward, DJ,et al. Coding of peripheral electrical stimulation frequency in thalamocortical pathways[J]. EXPERIMENTAL NEUROLOGY,2005,196(1):138-152.
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