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学科主题: 临床医学
题名:
The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation
作者: Sun, Yu-Qian1; He, Gan-Lin1; Chang, Ying-Jun1; Xu, Lan-Ping1; Zhang, Xiao-Hui1; Han, Wei1; Chen, Huan1; Chen, Yu-Hong1; Wang, Yu1; Wang, Feng-Rong1; Wang, Jing-Zhi1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
关键词: Graft function ; Haploidentical ; Stem cell transplantation ; Human leukocyte antigen
刊名: ANNALS OF HEMATOLOGY
发表日期: 2015-10-01
DOI: 10.1007/s00277-015-2440-x
卷: 94, 期:10, 页:1699-1705
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: ACQUIRED APLASTIC-ANEMIA ; MARROW TRANSPLANTATION ; BLOOD ; FAILURE ; BOOST
英文摘要:

Primary poor graft function (PGF) is a severe complication after allogeneic stem cell transplantation (SCT). The incidence, risk factors, and outcomes of PGF have not been well described, especially in the haploidentical SCT setting. We retrospectively reviewed patients who received haploidentical SCT at Peking University Institute of Hematology between January 1, 2011, and December 31, 2012. PGF was defined as persistent neutropenia (a parts per thousand currency sign0.5 x 10(9) L-1), thrombocytopenia (platelets a parts per thousand currency sign20 x 10(9) L-1), and/or hemoglobin a parts per thousand currency sign70 g L-1 after engraftment with hypocellular bone marrow and full donor chimerism, without concurrent graft-versus-host disease or disease relapse. Incidence was calculated from all patients. Of the 464 total patients, 26 (5.6 %) developed primary PGF. The risk factors were analyzed and compared with control patients with good graft function who were selected using the case-pair method. Finally, 104 patients were selected as a control group according to the matching conditions: (1) the type (acute leukemia, myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML)) and status (standard risk, high risk) of underlying disease, (2) sex, (3) year in which the transplantation was received, and (4) a 1:4 ratio of case-control. No factors were found to be associated with primary PGF. Compared to cases with good graft function, patients with primary PGF experienced poor overall survival (34.6 vs. 82.7 %, p < 0.001). Of the 26 primary PGF patients, only nine achieved hematopoietic recovery and survived. In conclusion, primary PGF is a rare but life-threatening complication after haploidentical SCT, and effective therapies need to be explored.

语种: 英语
所属项目编号: 2013AA020401 ; 81230013 ; 2011-4022-08
项目资助者: National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development
WOS记录号: WOS:000360665000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56345
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Yu-Qian,He, Gan-Lin,Chang, Ying-Jun,et al. The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation[J]. ANNALS OF HEMATOLOGY,2015,94(10):1699-1705.
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