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学科主题临床医学
The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation
Sun, Yu-Qian1; He, Gan-Lin1; Chang, Ying-Jun1; Xu, Lan-Ping1; Zhang, Xiao-Hui1; Han, Wei1; Chen, Huan1; Chen, Yu-Hong1; Wang, Yu1; Wang, Feng-Rong1; Wang, Jing-Zhi1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
关键词Graft Function Haploidentical Stem Cell Transplantation Human Leukocyte Antigen
刊名ANNALS OF HEMATOLOGY
2015-10-01
DOI10.1007/s00277-015-2440-x
94期:10页:1699-1705
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]ACQUIRED APLASTIC-ANEMIA ; MARROW TRANSPLANTATION ; BLOOD ; FAILURE ; BOOST
英文摘要

Primary poor graft function (PGF) is a severe complication after allogeneic stem cell transplantation (SCT). The incidence, risk factors, and outcomes of PGF have not been well described, especially in the haploidentical SCT setting. We retrospectively reviewed patients who received haploidentical SCT at Peking University Institute of Hematology between January 1, 2011, and December 31, 2012. PGF was defined as persistent neutropenia (a parts per thousand currency sign0.5 x 10(9) L-1), thrombocytopenia (platelets a parts per thousand currency sign20 x 10(9) L-1), and/or hemoglobin a parts per thousand currency sign70 g L-1 after engraftment with hypocellular bone marrow and full donor chimerism, without concurrent graft-versus-host disease or disease relapse. Incidence was calculated from all patients. Of the 464 total patients, 26 (5.6 %) developed primary PGF. The risk factors were analyzed and compared with control patients with good graft function who were selected using the case-pair method. Finally, 104 patients were selected as a control group according to the matching conditions: (1) the type (acute leukemia, myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML)) and status (standard risk, high risk) of underlying disease, (2) sex, (3) year in which the transplantation was received, and (4) a 1:4 ratio of case-control. No factors were found to be associated with primary PGF. Compared to cases with good graft function, patients with primary PGF experienced poor overall survival (34.6 vs. 82.7 %, p < 0.001). Of the 26 primary PGF patients, only nine achieved hematopoietic recovery and survived. In conclusion, primary PGF is a rare but life-threatening complication after haploidentical SCT, and effective therapies need to be explored.

语种英语
WOS记录号WOS:000360665000009
项目编号2013AA020401 ; 81230013 ; 2011-4022-08
资助机构National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56345
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
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GB/T 7714
Sun, Yu-Qian,He, Gan-Lin,Chang, Ying-Jun,et al. The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation[J]. ANNALS OF HEMATOLOGY,2015,94(10):1699-1705.
APA Sun, Yu-Qian.,He, Gan-Lin.,Chang, Ying-Jun.,Xu, Lan-Ping.,Zhang, Xiao-Hui.,...&Huang, Xiao-Jun.(2015).The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation.ANNALS OF HEMATOLOGY,94(10),1699-1705.
MLA Sun, Yu-Qian,et al."The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation".ANNALS OF HEMATOLOGY 94.10(2015):1699-1705.
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