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学科主题: 临床医学
题名:
Clinical study on the correlation between metabolic syndrome and colorectal carcinoma
作者: Shen, Zhanlong; Wang, Shan; Ye, Yingjiang; Yin, Mujun; Yang, Xiaodong; Jiang, Kewei; Liu, Yan
关键词: blood lipid obesity ; body mass index ; clinicopathologic parameter ; colonic carcinoma ; insulin resistance ; liver metastases ; metabolic syndrome ; rectal carcinoma ; recurrence ; survival
刊名: ANZ JOURNAL OF SURGERY
发表日期: 2010-05-01
DOI: 10.1111/j.1445-2197.2009.05084.x
卷: 80, 期:5, 页:331-336
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: GROWTH-FACTOR ; INSULIN-RESISTANCE ; CANCER MORTALITY ; BODY-SIZE ; RISK ; OBESITY ; MEN
英文摘要:

Background:

Although metabolic syndrome (MS) has received a lot of attention in recent years, the correlation between MS and colorectal carcinoma is still not very clear. This study aims at exploring the relationship between MS and colorectal carcinoma.

Methods:

Data was collected from 507 cases of colorectal carcinoma and 507 cases of healthy patients between January 2002 and March 2007 to establish the database. The patients with colorectal cancer were divided into two groups based on the presence of MS. Multivariate analysis of these data for the overall survival and recurrence was performed with the Cox proportional hazard model. Variables examined by multivariate analysis were sex , age, location, histotype, differentiation, tumour, node, metastasis (TNM) stage, the number of lymph nodes detected, etc.

Results:

The existence of MS in the colorectal carcinoma group was clearly more than that in the control group. The existence of two to four types of abnormal metabolic diseases was significantly more in the colorectal cancer group than in the control group. MS is one of the important elements that can independently influence the survival (odds ratio (OR) = 1.501, 95% confidence interval (CI) = 1.057-2.131) and have the highest risk with worse survival compared with other parameters.

Conclusion:

There is a close relationship between MS and colorectal carcinoma, and MS is a significantly independent element that influences the survival of the colorectal carcinoma. Decreasing the incidence of MS maybe play a role in improving therapeutic efficacy and prognosis of the cancer.

语种: 英语
WOS记录号: WOS:000277401300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56354
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Shen, Zhanlong,Wang, Shan,Ye, Yingjiang,et al. Clinical study on the correlation between metabolic syndrome and colorectal carcinoma[J]. ANZ JOURNAL OF SURGERY,2010,80(5):331-336.
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