IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Clinical study on the correlation between metabolic syndrome and colorectal carcinoma
Shen, Zhanlong; Wang, Shan; Ye, Yingjiang; Yin, Mujun; Yang, Xiaodong; Jiang, Kewei; Liu, Yan
关键词Blood Lipid Obesity Body Mass Index Clinicopathologic Parameter Colonic Carcinoma Insulin Resistance Liver Metastases Metabolic Syndrome Rectal Carcinoma Recurrence Survival
刊名ANZ JOURNAL OF SURGERY
2010-05-01
DOI10.1111/j.1445-2197.2009.05084.x
80期:5页:331-336
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]GROWTH-FACTOR ; INSULIN-RESISTANCE ; CANCER MORTALITY ; BODY-SIZE ; RISK ; OBESITY ; MEN
英文摘要

Background:

Although metabolic syndrome (MS) has received a lot of attention in recent years, the correlation between MS and colorectal carcinoma is still not very clear. This study aims at exploring the relationship between MS and colorectal carcinoma.

Methods:

Data was collected from 507 cases of colorectal carcinoma and 507 cases of healthy patients between January 2002 and March 2007 to establish the database. The patients with colorectal cancer were divided into two groups based on the presence of MS. Multivariate analysis of these data for the overall survival and recurrence was performed with the Cox proportional hazard model. Variables examined by multivariate analysis were sex , age, location, histotype, differentiation, tumour, node, metastasis (TNM) stage, the number of lymph nodes detected, etc.

Results:

The existence of MS in the colorectal carcinoma group was clearly more than that in the control group. The existence of two to four types of abnormal metabolic diseases was significantly more in the colorectal cancer group than in the control group. MS is one of the important elements that can independently influence the survival (odds ratio (OR) = 1.501, 95% confidence interval (CI) = 1.057-2.131) and have the highest risk with worse survival compared with other parameters.

Conclusion:

There is a close relationship between MS and colorectal carcinoma, and MS is a significantly independent element that influences the survival of the colorectal carcinoma. Decreasing the incidence of MS maybe play a role in improving therapeutic efficacy and prognosis of the cancer.

语种英语
WOS记录号WOS:000277401300010
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56354
专题北京大学第二临床医学院_胃肠外科
作者单位Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Shen, Zhanlong,Wang, Shan,Ye, Yingjiang,et al. Clinical study on the correlation between metabolic syndrome and colorectal carcinoma[J]. ANZ JOURNAL OF SURGERY,2010,80(5):331-336.
APA Shen, Zhanlong.,Wang, Shan.,Ye, Yingjiang.,Yin, Mujun.,Yang, Xiaodong.,...&Liu, Yan.(2010).Clinical study on the correlation between metabolic syndrome and colorectal carcinoma.ANZ JOURNAL OF SURGERY,80(5),331-336.
MLA Shen, Zhanlong,et al."Clinical study on the correlation between metabolic syndrome and colorectal carcinoma".ANZ JOURNAL OF SURGERY 80.5(2010):331-336.
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