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Cytotoxic steroidal saponins from Ophiopogon japonicus
Li, Ning; Zhang, Liang; Zeng, Ke-Wu; Zhou, Yuan; Zhang, Jia-Yu; Che, Yan-Yun; Tu, Peng-Fei
关键词Ophiopogon Japonicus Steroidal Saponins Cytotoxic Activity
刊名STEROIDS
2013
DOI10.1016/j.steroids.2012.10.001
78期:1页:1-7
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]THUNB. KER-GAWL ; GLYCOSIDES ; TUBERS
英文摘要

Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000314432500001
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56356
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第三临床医学院_麻醉科
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Ning,Zhang, Liang,Zeng, Ke-Wu,et al. Cytotoxic steroidal saponins from Ophiopogon japonicus[J]. STEROIDS,2013,78(1):1-7.
APA Li, Ning.,Zhang, Liang.,Zeng, Ke-Wu.,Zhou, Yuan.,Zhang, Jia-Yu.,...&Tu, Peng-Fei.(2013).Cytotoxic steroidal saponins from Ophiopogon japonicus.STEROIDS,78(1),1-7.
MLA Li, Ning,et al."Cytotoxic steroidal saponins from Ophiopogon japonicus".STEROIDS 78.1(2013):1-7.
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