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学科主题: 药学
题名:
Cytotoxic steroidal saponins from Ophiopogon japonicus
作者: Li, Ning; Zhang, Liang; Zeng, Ke-Wu; Zhou, Yuan; Zhang, Jia-Yu; Che, Yan-Yun; Tu, Peng-Fei
关键词: Ophiopogon japonicus ; Steroidal saponins ; Cytotoxic activity
刊名: STEROIDS
发表日期: 2013
DOI: 10.1016/j.steroids.2012.10.001
卷: 78, 期:1, 页:1-7
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: THUNB. KER-GAWL ; GLYCOSIDES ; TUBERS
英文摘要:

Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000314432500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56356
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Ning,Zhang, Liang,Zeng, Ke-Wu,et al. Cytotoxic steroidal saponins from Ophiopogon japonicus[J]. STEROIDS,2013,78(1):1-7.
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