IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells
Zhang, Junling1; Wang, Pengyuan1; Zhu, Jing1; Wang, Wei1; Yin, Jie1; Zhang, Chi2; Chen, Ziyi1; Sun, Lie1; Wan, Yuanlian1; Wang, Xin1; Chen, Guowei1; Liu, Yucun1
关键词Sparc Vegfr2 Proliferation Clonogenicity Invasion Gastric Cancer
刊名ONCOLOGY REPORTS
2014-05-01
DOI10.3892/or.2014.3118
31期:5页:2312-2320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]AORTIC ENDOTHELIAL-CELLS ; PROTEIN EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; COLON-CANCER ; PROGRESSION ; OVEREXPRESSION ; CYSTEINE ; RICH
英文摘要

Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relationship between SPARC expression and clinicopathological factors of gastric cancer (GC) is controversial, and the role of SPARC in GC remains unclear. We evaluated expression of SPARC in 65 human GC tissues using immunohistochemistry (IHC). The results indicated that SPARC expression was negatively correlated with clinicopathological factors of GC. In vitro assay showed that SPARC overexpression decreased proliferation and clonogenicity by suppressing CD44 expression. In addition, SPARC overexpression inhibited VEGF induced proliferation and arrested cell cycle of GC cells by reducing the activation of VEGFR2, ERK1/2 and AKT signaling pathways. SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression. In the in vivo assay, cancer metastasis mouse models were established by tail vein injection. The results revealed that the lung metastases of SPARC-overexpressing GC cells in the mice were much fewer than those of control cells.

语种英语
WOS记录号WOS:000337947200045
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56366
专题北京大学第一临床医学院_普通外科
作者单位1.Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China
2.Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250021, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Junling,Wang, Pengyuan,Zhu, Jing,et al. SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells[J]. ONCOLOGY REPORTS,2014,31(5):2312-2320.
APA Zhang, Junling.,Wang, Pengyuan.,Zhu, Jing.,Wang, Wei.,Yin, Jie.,...&Liu, Yucun.(2014).SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells.ONCOLOGY REPORTS,31(5),2312-2320.
MLA Zhang, Junling,et al."SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells".ONCOLOGY REPORTS 31.5(2014):2312-2320.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Junling]的文章
[Wang, Pengyuan]的文章
[Zhu, Jing]的文章
百度学术
百度学术中相似的文章
[Zhang, Junling]的文章
[Wang, Pengyuan]的文章
[Zhu, Jing]的文章
必应学术
必应学术中相似的文章
[Zhang, Junling]的文章
[Wang, Pengyuan]的文章
[Zhu, Jing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。