北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科  > 期刊论文
学科主题: 临床医学
题名:
SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells
作者: Zhang, Junling1; Wang, Pengyuan1; Zhu, Jing1; Wang, Wei1; Yin, Jie1; Zhang, Chi2; Chen, Ziyi1; Sun, Lie1; Wan, Yuanlian1; Wang, Xin1; Chen, Guowei1; Liu, Yucun1
关键词: SPARC ; VEGFR2 ; proliferation ; clonogenicity ; invasion ; gastric cancer
刊名: ONCOLOGY REPORTS
发表日期: 2014-05-01
DOI: 10.3892/or.2014.3118
卷: 31, 期:5, 页:2312-2320
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: AORTIC ENDOTHELIAL-CELLS ; PROTEIN EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; COLON-CANCER ; PROGRESSION ; OVEREXPRESSION ; CYSTEINE ; RICH
英文摘要:

Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relationship between SPARC expression and clinicopathological factors of gastric cancer (GC) is controversial, and the role of SPARC in GC remains unclear. We evaluated expression of SPARC in 65 human GC tissues using immunohistochemistry (IHC). The results indicated that SPARC expression was negatively correlated with clinicopathological factors of GC. In vitro assay showed that SPARC overexpression decreased proliferation and clonogenicity by suppressing CD44 expression. In addition, SPARC overexpression inhibited VEGF induced proliferation and arrested cell cycle of GC cells by reducing the activation of VEGFR2, ERK1/2 and AKT signaling pathways. SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression. In the in vivo assay, cancer metastasis mouse models were established by tail vein injection. The results revealed that the lung metastases of SPARC-overexpressing GC cells in the mice were much fewer than those of control cells.

语种: 英语
所属项目编号: 30901417/H1617
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000337947200045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56366
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China
2.Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250021, Shandong, Peoples R China

Recommended Citation:
Zhang, Junling,Wang, Pengyuan,Zhu, Jing,et al. SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells[J]. ONCOLOGY REPORTS,2014,31(5):2312-2320.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Junling]'s Articles
[Wang, Pengyuan]'s Articles
[Zhu, Jing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Junling]‘s Articles
[Wang, Pengyuan]‘s Articles
[Zhu, Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace