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Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers
Ma, Hui Li1; Xu, Yu Feng2; Qi, Xian Rong1; Maitani, Yoshie3; Nagai, Tsuneji4
关键词Superparamagnetic Iron Oxide Nanoparticles (Spio) Pharmacokinetics Distribution Liver Cancers Contrast Agent Alginate
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2008-04-16
DOI10.1016/j.ijpharm.2007.11.036
354期:1-2页:217-226
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]MR CONTRAST AGENT ; HEPATOCELLULAR-CARCINOMA ; BIOMEDICAL APPLICATIONS ; RAT-LIVER ; PARTICLES ; INJECTION ; CIRRHOSIS ; ENHANCEMENT ; IMAGES ; TUMORS
英文摘要

The objectives of this study were to describe the pharmacokinetics and tissue distribution of superparamagnetic iron oxide nanoparticle (SPIO) stabilized with alginate (SPIO-alginate), and investigate its potential in detecting liver cancers as a newly developed magnetic resonance (MR) contrast agent. Pharmacokinetics and tissue distribution of SPIO-alginate were investigated in Sprague-Dawley rats. The results showed that SPIO-alginate was eliminated rapidly from serum with the half-life of 0.27 h at 109.5 mu mol Fe/kg and accumulated dominantly in liver and spleen with a total percentage of more than 90% of dose after intravenous injection. The studies of pharmacokinetics and distribution of SPIO-alginate in rats indicated the MR contrast agent, based on SPIO, mainly accumulating in targeting organs that contain phagocytosing cells, i.e. liver and spleen. The efficacies in detecting hepatocellular carcinoma (HCC) of rat with primary liver cancer and xenograft liver cancers of rabbit were investigated before and after injection of SPIO-alginate. The signal intensity of Ever parenchyma in rabbit with VX2 tumor after injection of SPIO-alginate was reduced sharply resulting in a significant contrast between liver parenchyma and tumor. Detection of the HCC in rat model was also demonstrated. The present study provides evidence that SPIO-alginate might have the ability to improve the detection of liver tumors as an MR contrast agent, and the efficacy is associated with the SPIO specifically located in Kupffer cells in hepatic sinusoid. (C) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000255320100031
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56390
专题北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Inst Med Chem, Tokyo 1428501, Japan
2.Nagai Fdn Tokyo, Bunkyo Ku, Tokyo 1130021, Japan
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ma, Hui Li,Xu, Yu Feng,Qi, Xian Rong,et al. Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,354(1-2):217-226.
APA Ma, Hui Li,Xu, Yu Feng,Qi, Xian Rong,Maitani, Yoshie,&Nagai, Tsuneji.(2008).Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,354(1-2),217-226.
MLA Ma, Hui Li,et al."Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 354.1-2(2008):217-226.
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