北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo
作者: Lu, Jingkai1; Chuan, Xingxing1; Zhang, Hua1; Dai, Wenbing1; Wang, Xinglin2; Wang, Xueqing1; Zhang, Qiang1
关键词: Paclitaxel ; PEGylated paclitaxel ; PEG-PLA ; Taxol ; Nanoparticles ; Antitumor effect
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2014-08-25
DOI: 10.1016/j.ijpharm.2014.05.032
卷: 471, 期:1-2, 页:525-535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: POLYMERIC MICELLE FORMULATION ; DRUG-DELIVERY SYSTEMS ; PHASE-II TRIAL ; CREMOPHOR-FREE ; GENEXOL-PM ; LUNG-CANCER ; EFFICACY ; PRODRUGS ; SOLUBILITY ; CONJUGATE
英文摘要:

Previously, PEGylated paclitaxel (PEG-PTX) was found not favorable as a polymer prodrug because of its poor antitumor efficiency. But surprisingly, it was found in our study that PEG-PTX could form a novel nanoparticle system with free PTX. To address how this system works, we compared PTX loaded PEG-PTX nanoparticles (PEG-PTX/PTX) with PTX loaded PEG-PLA micelles (PEG-PLA/PTX) or PTX injection available (Taxol((R))) in vitro and in vivo. Firstly, it was found that PEG-PTX/PTX was more stable in aqueous solution than PEG-PLA/PTX in terms of PTX crystal formation and drug release. Then it was demonstrated that coumarin loaded PEG-PTX nanoparticles had a much higher uptake in MCF-7 cells compared to coumarin loaded PEG-PLA micelles. The in vivo imaging study revealed that DIR or DID (near infrared fluorescent substances) loaded PEG-PTX nanoparticles distributed more in tumors in MCF-7 tumor bearing mice than DIR or DID loaded PEG-PLA micelles and solvent system of Taxol((R)). In the efficacy study with MCF-7 tumor bearing mice, PEG-PTX/PTX showed significantly higher antitumor activity than PEG-PLA/PTX at the same PTX dosage. At the dose of 10 mg free PTX per kg, PEG-PTX/PTX displayed similar efficacy as Taxol((R)) but less toxicity evaluated by the loss of body weight. With the increase of free PTX to 15 mg/kg, PEG-PTX/PTX showed significantly better efficacy than Taxol((R)). In conclusion, with favorable characteristics in stability, cellular uptake, cytotoxicity, biodistribution, safety and efficacy, PEG-PTX/PTX seems highly potential as a nanocarrier for PTX delivery. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81130059 ; 81273456 ; 2012CB724002
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000338423600059
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56392
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China

Recommended Citation:
Lu, Jingkai,Chuan, Xingxing,Zhang, Hua,et al. Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2014,471(1-2):525-535.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lu, Jingkai]'s Articles
[Chuan, Xingxing]'s Articles
[Zhang, Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lu, Jingkai]‘s Articles
[Chuan, Xingxing]‘s Articles
[Zhang, Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace