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学科主题基础医学
Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats
Tian, DR; Li, XD; Shi, YS; Wan, Y; Wang, XM; Chang, JK; Yang, J; Han, JS
关键词cocaine and amphetamine-regulated transcript peptide alpha-melanocyte-stimulating hormone diet-induced obesity high-fat diet hypothalamus
刊名PEPTIDES
2004-12-01
DOI10.1016/j.peptides.2004.08.009
25期:12页:2147-2153
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]AMPHETAMINE-REGULATED TRANSCRIPT ; MESSENGER-RNA EXPRESSION ; NEUROPEPTIDE-Y ; BODY-WEIGHT ; MELANOCORTIN SYSTEM ; ENERGY HOMEOSTASIS ; FEEDING-BEHAVIOR ; LEPTIN RECEPTOR ; RESISTANT RATS ; MOUSE-BRAIN
英文摘要

Two hypothalamic peptides, cocaine and amphetamine-regulated transcript (CART) and a-melanocyte-stimulating. hormone (a-ASH). recognized as anorexigenic neuropeptides to suppress the feeding behavior. were monitored in rats fed with a high-fat (HIF) diet for 14 weeks. While half of the rats developed obesity (diet-induced obese, DIO), some did not (diet resistant. DR). Compared to the DR rats and the control rats (fed with standard chow), DIO rats were accompanied by a markedly higher energy intake and a decrease in the number of neurons carrying alpha-MSH and CART peptide in the arcuate nucleus of the hypothalamus. Failure of hypmhalamic anorexigenic peptides CART and alpha-MSH to increase their content in response to HIF diet may play a key role for overly high energy consumption. resulting in obesity. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000226186200014
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56397
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
3.Tianjin Med Univ, Dept Anat, Tianjin 300070, Peoples R China
推荐引用方式
GB/T 7714
Tian, DR,Li, XD,Shi, YS,et al. Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats[J]. PEPTIDES,2004,25(12):2147-2153.
APA Tian, DR.,Li, XD.,Shi, YS.,Wan, Y.,Wang, XM.,...&Han, JS.(2004).Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats.PEPTIDES,25(12),2147-2153.
MLA Tian, DR,et al."Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats".PEPTIDES 25.12(2004):2147-2153.
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