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学科主题: 临床医学
题名:
Pros and cons for C4d as a biomarker
作者: Cohen, Danielle1; Colvin, Robert B.2; Daha, Mohamed R.3; Drachenberg, Cinthia B.4; Haas, Mark5; Nickeleit, Volker6; Salmon, Jane E.7; Sis, Banu8; Zhao, Ming-Hui9; Bruijn, Jan A.1; Bajema, Ingeborg M.1
关键词: acute allograft rejection ; chronic rejection ; complement ; transplantation ; transplant pathology
刊名: KIDNEY INTERNATIONAL
发表日期: 2012-04-01
DOI: 10.1038/ki.2011.497
卷: 81, 期:7, 页:628-639
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTIBODY-MEDIATED REJECTION ; RENAL-ALLOGRAFT REJECTION ; DONOR-SPECIFIC ANTIBODIES ; KIDNEY-TRANSPLANT RECIPIENTS ; COMPLEMENT ACTIVATION ; HUMORAL REJECTION ; GLOMERULAR C4D ; PERITUBULAR CAPILLARIES ; LUPUS NEPHRITIS ; HLA ANTIBODIES
英文摘要:

The introduction of C4d in daily clinical practice in the late nineties aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. As a marker of classical complement activation, C4d made it possible to visualize the direct link between anti-donor antibodies and tissue injury at sites of antibody binding in a graft. With the expanding use of C4d worldwide several limitations of C4d were identified. For instance, in ABO-incompatible transplantations C4d is present in the majority of grafts but this seems to point at ′graft accommodation′ rather than antibody-mediated rejection. C4d is now increasingly recognized as a potential biomarker in other fields where antibodies can cause tissue damage, such as systemic autoimmune diseases and pregnancy. In all these fields, C4d holds promise to detect patients at risk for the consequences of antibody-mediated disease. Moreover, the emergence of new therapeutics that block complement activation makes C4d a marker with potential to identify patients who may possibly benefit from these drugs. This review provides an overview of the past, present, and future perspectives of C4d as a biomarker, focusing on its use in solid organ transplantation and discussing its possible new roles in autoimmunity and pregnancy. Kidney International (2012) 81, 628-639; doi:10.1038/ki.2011.497; published online 1 February 2012

语种: 英语
WOS记录号: WOS:000301847900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56399
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
2.Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RC Leiden, Netherlands
3.Leiden Univ, Med Ctr, Dept Immunol & Renal Dis, NL-2300 RC Leiden, Netherlands
4.Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA
5.Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA
6.Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
7.Hosp Special Surg, Weill Cornell Med Coll, New York, NY 10021 USA
8.Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2M7, Canada
9.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China

Recommended Citation:
Cohen, Danielle,Colvin, Robert B.,Daha, Mohamed R.,et al. Pros and cons for C4d as a biomarker[J]. KIDNEY INTERNATIONAL,2012,81(7):628-639.
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