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Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex
Ke, Xiaoyan1,2; Wang, Jing1,2; Li, Lijuan1,2; Chen, Irene H.3; Wang, Hong3; Yang, Xiao-Feng3
关键词cd4+cd25(High)foxp3+regulatory t Cells Anti-tumor Immunotherapy Immunosuppression Lymphomas Tumors Review
刊名FRONTIERS IN BIOSCIENCE
2008-05-01
DOI10.2741/2986
13页:3986-4001
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]REGULATORY T-CELLS ; CHRONIC MYELOGENOUS LEUKEMIA ; TRANSCRIPTION FACTOR FOXP3 ; FOSTERS IMMUNE PRIVILEGE ; IMMUNOSTIMULATORY MONOCLONAL-ANTIBODIES ; NON-HODGKINS-LYMPHOMA ; INDUCED TNF RECEPTOR ; CANCER STEM-CELLS ; IN-VIVO ; CUTTING EDGE
英文摘要

CD4+CD25(high)FOXP3+ regulatory T cells (Tregs) play an important role in the maintenance of immunological self-tolerance by suppressing autoimmune responses and anti-tumor immune responses. The current model suggests that epithelial tumor cells recruit Tregs to inhibit anti-tumor immunity in the tumor microenvironment, which thus limits the efficiency of antitumor immune responses and immunotherapy. However, recent findings on Tregs in lymphomas have complicated this working model. The biopsy specimens of some lymphomas have significantly higher percentages of Tregs than that in tumor-free lymph nodes and normal peripheral mononuclear cells. Higher Tregs numbers in these lymphomas predict improved survival and prognosis of patients. In this brief review, we summarize the progress in following topics: (1) Tregs; (2) Tregs and T cell co-stimulation; (3) Tregs in lymphomas; and (4) Tregs in other Tumors. Further characterization of Tregs in lymphomas and other tumors will provide insight on the differential regulation of Tregs′ function and survival, and define the potentials of Tregs-based immunotherapeutics.

语种英语
WOS记录号WOS:000255885000066
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56400
专题北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100083, Peoples R China
3.Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
推荐引用方式
GB/T 7714
Ke, Xiaoyan,Wang, Jing,Li, Lijuan,et al. Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex[J]. FRONTIERS IN BIOSCIENCE,2008,13:3986-4001.
APA Ke, Xiaoyan,Wang, Jing,Li, Lijuan,Chen, Irene H.,Wang, Hong,&Yang, Xiao-Feng.(2008).Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex.FRONTIERS IN BIOSCIENCE,13,3986-4001.
MLA Ke, Xiaoyan,et al."Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex".FRONTIERS IN BIOSCIENCE 13(2008):3986-4001.
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