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学科主题: 临床医学
题名:
Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex
作者: Ke, Xiaoyan1,2; Wang, Jing1,2; Li, Lijuan1,2; Chen, Irene H.3; Wang, Hong3; Yang, Xiao-Feng3
关键词: CD4+CD25(high)FOXP3+regulatory T cells ; anti-tumor immunotherapy ; immunosuppression ; lymphomas ; tumors ; review
刊名: FRONTIERS IN BIOSCIENCE
发表日期: 2008-05-01
DOI: 10.2741/2986
卷: 13, 页:3986-4001
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: REGULATORY T-CELLS ; CHRONIC MYELOGENOUS LEUKEMIA ; TRANSCRIPTION FACTOR FOXP3 ; FOSTERS IMMUNE PRIVILEGE ; IMMUNOSTIMULATORY MONOCLONAL-ANTIBODIES ; NON-HODGKINS-LYMPHOMA ; INDUCED TNF RECEPTOR ; CANCER STEM-CELLS ; IN-VIVO ; CUTTING EDGE
英文摘要:

CD4+CD25(high)FOXP3+ regulatory T cells (Tregs) play an important role in the maintenance of immunological self-tolerance by suppressing autoimmune responses and anti-tumor immune responses. The current model suggests that epithelial tumor cells recruit Tregs to inhibit anti-tumor immunity in the tumor microenvironment, which thus limits the efficiency of antitumor immune responses and immunotherapy. However, recent findings on Tregs in lymphomas have complicated this working model. The biopsy specimens of some lymphomas have significantly higher percentages of Tregs than that in tumor-free lymph nodes and normal peripheral mononuclear cells. Higher Tregs numbers in these lymphomas predict improved survival and prognosis of patients. In this brief review, we summarize the progress in following topics: (1) Tregs; (2) Tregs and T cell co-stimulation; (3) Tregs in lymphomas; and (4) Tregs in other Tumors. Further characterization of Tregs in lymphomas and other tumors will provide insight on the differential regulation of Tregs′ function and survival, and define the potentials of Tregs-based immunotherapeutics.

语种: 英语
WOS记录号: WOS:000255885000066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56400
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100083, Peoples R China
3.Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA

Recommended Citation:
Ke, Xiaoyan,Wang, Jing,Li, Lijuan,et al. Roles of CD4+CD25(high)FOXP3+ tregs in lymphomas and tumors are complex[J]. FRONTIERS IN BIOSCIENCE,2008,13:3986-4001.
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